DNA Damage

1. Gene Function Role DNA Damage PRKDC DNA-PK catalytic subunit DNA Damage Signalling GADD45A CDK Binding DNA Damage Response CIB1 Unknown DNA end joining MSH2 DNA Mismatch Recognition Mismatch Repair XRCC5 DNA Helicase Non-homologous end joining Metabolism NDUFV2 Oxidoreductase Electron Transport TYMS dTMP synthetase Nucleotide Metabolism GOT2 Transaminase Amino Acid Metabolism GSTM3 Glutathione S-transferase Xenobiotic Metabolism GLB1 Galactosidase Ganglioside Metabolism NDUFS1 Oxidoreductase Electron Transport MAT2A AdoMet Synthesis Methionine Metabolism GLO1 Glyoxalase Glutathionine Metabolism GPX4 Peroxidase Hydrogen Peroxide Protection ALDOC Fructose Aldolase Carbohydrate Metabolism BLVRA Biliverdin Reductase Redox Cycle ACADS Acyl-coenzyme A dehydrogenase Fatty Acid Metabolism GSTZ1 Glutathione S-transferase Amino Acid Catabolism ALDOC Aldolase Glycolysis Apoptosis SIAH2 E3 Ligase Apoptosis BCL2L1 Bcl-2 family member Anti-Apoptotic DNASE1L3 DNAse DNA Cleavage CASP4 Caspase Pro-Apoptotic SIVA TNFR family member Pro-Apoptotic Cell Signalling CREM Transcription Factor cAMP Signalling RREB1 Transcription Factor MAPK Signalling MAPK1 Mitogen Signalling MAPK Signalling GRB10 Mitogen Signalling Growth Factor Signalling MAP2K1 Mitogen Signalling MAPK Signalling RAB3A Ras Associated Signalling CTNND2 Cadherin Signalling Signalling PIK3CB inositide kinase Mitogen Signalling RANBP1 RAN Binding Signalling GNB1 G-Protein Signalling IFNAR2 Inteferon Receptor JAK/STAT Signalling NOTCH4 Notch Signalling Signalling Sub-Polysome Polysome Table S1: mRNAs Upregulated during TRAIL induced apoptosis