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PROBIOTICS IN HEALTH & DISEASE

PROBIOTICS IN HEALTH & DISEASE . www.triphasepharma.com. An ISO9001:2008 Certified Company. What are Probiotics ? Potential Mechanisms of Action Therapeutic Targets of Probiotics Strain Specificity Quality Control. PROBIOTICS.

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PROBIOTICS IN HEALTH & DISEASE

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  1. PROBIOTICS IN HEALTH & DISEASE www.triphasepharma.com An ISO9001:2008 Certified Company

  2. What are Probiotics? • Potential Mechanisms of Action • Therapeutic Targets of Probiotics • Strain Specificity • Quality Control Private & Confidential

  3. PROBIOTICS • “Live microorganisms which when administered in adequate amounts confer a health benefit on the host” • Probiotic microorganisms can be found in both supplement form and as components of foods and beverages. Private & Confidential

  4. TYPES OF PROBIOTIC • Lactobacillus - Most available are species are, • - L.acidophilus • -L.casei • - L.reuterii • - L.rhamnosus • - L.bulgaricus • - L.plantarum • Bifidobacteria- Most available are species are, • -B.infantis • - B.longum • - B.bifidum • - B.lactis • Saccharomyces boulardii – Widely studied probioticyeast • Saccharomyces cerevisiae- Most used probiotic strain for varied applications Private & Confidential

  5. MECHANISM OF ACTION

  6. THERAPEUTIC TARGETS OF PROBIOTICS Gut Function Acute Diarrhea AAD, Travelers diarrhea C. difficileInf Lactose Indigestion IBS symptoms Gut pain sensation Inflammatory bowel Skin Microbiology, Inflammation • Oral Care • Dental caries • Allergy • Atopic dermatitis • Asthma • Metabolic Syndrome • Obesity, Diabetes Colds Respiratory Infections Vaginal Infection

  7. S. boulardiiIs Effective in Patients with Recurrent C. difficileDisease Initial CDD Recurrent CDD P=NS P=0.04 CDD recurrence, % CDD recurrence, % Control (n=34) S. boulardii (n=26) Placebo (n=33) S. boulardii (n=31) Patients received standard antibiotics (vancomycin or metronidazole) and S. boulardii 1 g/day or placebo for 4 weeks. CDD=Clostridium difficile-associated disease McFarland L, et al. JAMA. 1994;271:1913-1918.

  8. PROBIOTICS FOR PREVENTION OF ANTIBIOTIC ASSOCIATED DIARRHEA Mixtures included: Lactinex = L. acidophilus and L. bulgaricus; Lactobacillus acidophilus and Bifidobacteriumlactis; Lactobacillus acidophilus and Bifidobacteriuminfantis. McFarland, Am J Gastroenterol 2006; 101(4): 812-822.

  9. MISCONCEPTIONS ABOUT PROBIOTICS • Probiotics are live active cultures • More is not better • Dose (1 billion vs 10 billion vs 450 billion) • Number of strains • The effect of probiotics is genus specific

  10. DOSAGE & STRAINS OF PROBIOTICS • The dose of probiotics is usually expressed as the number of colony forming units (CFUs) • The required dose of probiotics may vary greatly for different strains and the specific health effect under investigation • Probiotic effects should be considered dose-specific • Dose listed on the label must be based on studies that show a health effect in humans • Different strains of the same species can be different • Clinical support to substantiate claims must be for each probiotic strain

  11. PROBIOTICS -QUALITY CONTROL • Source (Animal vs Human; Normal vs Diseased) • Safety (in at risk populations) • Characterization (strain purity) • Viability (Cfu Delivered) • Dose (Dose-response studies) • Combinations/cocktails (Different effects of different Bacterial,yeast strains)

  12. AWARENESS OF PROBIOTICS

  13. PROBIOTICS IN THE CURRENT MARKET PLACE

  14. ADVANTAGES OF YEAST PROBIOTIC COMPARE TO BACTERIAL PROBIOTICS

  15. Thank You. www.triphasepharma.com

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