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The Role of Transcription Factors and Growth Factors in Cellular Dynamics and Morphology

This study delves into the complex interactions between transcription factors, cytokines, and growth factors that govern cell behavior and morphology. It highlights key players such as COX-2, PAI-1, PAI-2, and various chemokines, elucidating their roles in pro-inflammatory, pro-fibrotic, and angiogenic processes. The research emphasizes feedback regulators, integrin signaling, and matrix remodeling, particularly through metalloproteases, over timeframes from 4 to 24 hours. Moreover, it discusses gene expression related to cell cycle arrest and morphogenetic changes.

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The Role of Transcription Factors and Growth Factors in Cellular Dynamics and Morphology

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  1. Transcription factors Cox-2 Chemokines Growth factors Feedback regulators Chemokines, Angiogenic factors, Pro-fibrotic factors PAI-1 Pro-inflammatory factors PAI-2 Integrin signaling Shape change Cell morphology Protein and lipid biosysnthesis Matrix remodeling Metalloproteases Cell movement 4-24 hrs 0.5 1 2 4 6 24 hrs Cell-cycle arrest genes, Slug, N-cadherin, Nedd9 CNN5 Additional file 7

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