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User Interfaces for University Laboratory Work cells

User Interfaces for University Laboratory Work cells. Malcolm Crook Process Analysis & Automation Lecturer, MChem Course, University of Surrey Lecturer, MSc Course Trinity College Dublin Advisory Board, University of Manchester. Purpose of presentation to show …. Software options

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User Interfaces for University Laboratory Work cells

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  1. User Interfaces for University Laboratory Work cells Malcolm Crook Process Analysis & AutomationLecturer, MChem Course, University of Surrey Lecturer, MSc Course Trinity College DublinAdvisory Board, University of Manchester

  2. Purpose of presentation to show … • Software options • Vendor specific • Vendor independent • Hardware options • Usually decided by user • Systems integration • Putting the system together • Tailoring projects • Making the system useable

  3. prepare sample prepare sample analyze sample analyze sample report results Laboratory automation - the process collect sample

  4. Key system requirements • Run a batch of plates • Run another batch of plates if present • Keep track of the data • Reliable • Easy to use

  5. Software Choices • Event driven/real-time scheduler/sequencer • Can handle timings • Can handle decisions • Can handle unknown plate quantities • Overlord2 is an EVENT DRIVEN SCHEDULER • Time driven/static scheduler • Handles multiple timings (incubations) • Overlord Scheduler is a TIME RESOLVED SCHEDULER

  6. STATIC EVENT DRIVEN hit the GO button hit the GO button know exactly what will happen at any time in the process Follow a process control and scheduling software

  7. Event driven scheduling Overlord2 real-time static scheduling OVERLORD Scheduler time driven Either control software - summary

  8. common features • support for over 300 instruments • data handling facilities • utilizes original instrument software • can integrate with most databases • SQL server, oracle, access • 21 CFR part 11 compliant • full system tracking • error notification • error recovery

  9. which product ? Overlord2 • Very Flexible • True Dynamic Scheduling • Takes longer to setup OVERLORD Scheduler • Cannot make decisions • Very easy to use • Obeys critical timings • Schedules fixed processes

  10. Overlord2 • real-time/event driven • icon based drag and drop set-up • flow chart interface • very flexible • dynamic scheduling • decisions can be made in real-time

  11. Software Structure Instrument Interface Instrument Interface Instrument Interface Run native instrument control software

  12. Software Structure Overlord2 Driver Overlord2 Driver Overlord2 Driver Written to access key functionality Instrument Interface Instrument Interface Instrument Interface Run native instrument control software

  13. Supervisor layer Software Structure Overlord2 Event driven Overlord2 Driver Overlord2 Driver Overlord2 Driver Written to access key functionality Instrument Interface Instrument Interface Instrument Interface Run native instrument control software

  14. Overlord2

  15. which product ? Overlord2 • Very Flexible • True Dynamic Scheduling • Takes longer to setup OVERLORD Scheduler • Cannot make decisions • Very easy to use • Obeys critical timings • Schedules fixed processes

  16. OVERLORD Scheduler • static/time driven • icon based drag and drop Gantt chart interface • optimise and interleave different assays • each assay run with exact incubation timings • very easy to create an assay • add new assays when the system is running

  17. OVERLORD Scheduler

  18. HARDWARE OPTIONS

  19. Most manufacturers Most instruments Over 300 instruments 450 licenses Used in USA Europe Japan Australia

  20. HARDWARE OPTIONS Plate transport

  21. Stackers PerkinElmer LS PlateStak Thermo RapidStak plate stacker Velocity 11 BenchCel Stacker Hudson PlateSilo Magstar Stacker Titertek Titan Robots automate.it KiNEDx SCARA arm Mitsubishi robots Staubli robots Caliper (Zymark) Twister I & II Thermo CataLyst 5 & X Denso VS-6556E robot Hamilton Microlab SWAP Hudson Plate Crane PAA X-Link Sands Technology robot range Plate transfer choice

  22. PE PlateStak Thermo RapidStak HARDWARE OPTIONS – stackers

  23. automate.it SCARA Mitsubishi HARDWARE OPTIONS - robots

  24. HARDWARE OPTIONS - robots

  25. HARDWARE OPTIONS Peripheral equipment

  26. High content plate reader Plate manipulator Peripherals HARDWARE OPTIONS- peripheral equipment

  27. Liquid Handling Reagent dispensing PlateWash Flexdrop HARDWARE OPTIONS - liquid handling

  28. HARDWARE OPTIONS Storage/containment

  29. Storage HARDWARE OPTIONS - storage • Inheco 12 place incubator • Thermo Cytomat range of incubators • Liconic range of incubators • Hamilton (TekCel) PlateStore • Thermo (Jouan) MolBank • Incubator • Caliper Scitec Carousel

  30. HARDWARE OPTIONS - containment • Bench workcell • automate.it SAFEcel • automate.it SAFEcel L • automate.it SAFEcel C2 • automate.it connect • 2 robot solution

  31. Systems Integration

  32. system what is an integrator ? • instruments are BRICKS • software is the CEMENT • integrator puts it together like a BUILDER hardware software integration

  33. example systems No stacker Stacker Robot Tracked robot

  34. no stacker or laboratory robot • PerkinElmer JANUS system http://www.paa.co.uk/ftp/labauto/videos/elisa_jpm_lo.wmv

  35. stacker only • automated TTP Mosquito system http://www.paa.co.uk/ftp/labauto/videos/nano_mosquito_lo.wmv • automated PerkinElmer PlateStak system http://www.paa.co.uk/ftp/labauto/videos/elisa_pe_lo.wmv

  36. laboratory robot systems • automated Genimic Solutions Hummingbird system http://www.paa.co.uk/ftp/labauto/videos/hummingbird_lo.wmv • automated GE Healthcare IN Cell 1000 system http://www.paa.co.uk/ftp/labauto/videos/hcs_1000_lo.wmv

  37. factory robot systems • automated dilute & seal system http://www.paa.co.uk/ftp/labauto/videos/mitsubishi_dilute_seal_lo.wmv • automated cell system http://www.paa.co.uk/ftp/labauto/videos/ppw_lo.wmv

  38. tracked robot system • Milk analysis workcell http://www.paa.co.uk/ftp/labauto/videos/milk_lo.wmv

  39. Tailoring systems

  40. Overlord2 - Customizable • user GUI & runtime module separable • can use different GUI, Microsoft Excel could be used • different run engines can be run • processes the flow using Overlord variables • overlord instrument drivers developed quickly • all components can be modified • master or slave • all errors handled with different options • .NET framework, API will be utilized • flexible GUI makes writing assays easier

  41. User layer Software Structure Experiment Manager Overlord2 Event driven Overlord2 Driver Overlord2 Driver Overlord2 Driver Written to access key functionality Instrument Interface Instrument Interface Instrument Interface Run native instrument control software

  42. Experiments added Experiment running Experiment complete Add an experiment Experiment Manager – User layer

  43. External collaborations Overlord2 • GE: Automation front ends • Molecular Devices StakMax • Labcyte 810 Pod: Automation layer • Caliper ACES programme • TAP: Automation layer • Matrical automated workcell OVERLORD Scheduler • PerkinElmer: JANUS Project Manager

  44. conclusion laboratory automation has a number of key stages • choice • hardware • software • scheduler choice • User front end choice • integration • make the system what was required not what was asked for • committed to technically relevant cost effective solution

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