1 / 12

MLH1 Mutations and the Formation of Hereditary Non-Polyposis Colon Cancer(Lynch Syndrome)

MLH1 Mutations and the Formation of Hereditary Non-Polyposis Colon Cancer(Lynch Syndrome). Kevin Harris. Some Families are Predisposed to Colon Cancer. What Genes Cause HNPCC?. MLH1 Encodes a DNA Mismatch Repair Protein. Meiotic Pachytene Arrest is Observed in MLH1-Deficient Mice.

corin
Télécharger la présentation

MLH1 Mutations and the Formation of Hereditary Non-Polyposis Colon Cancer(Lynch Syndrome)

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. MLH1 Mutations and the Formation of Hereditary Non-Polyposis Colon Cancer(Lynch Syndrome) Kevin Harris

  2. Some Families are Predisposed to Colon Cancer

  3. What Genes Cause HNPCC?

  4. MLH1 Encodes a DNA Mismatch Repair Protein

  5. Meiotic PachyteneArrest is Observed in MLH1-Deficient Mice

  6. MLH1 Mutants Lack MLH1 Protein and Make Many Replication Errors

  7. Molecular Markers Confirm MLH1 Mutations in HNPCC Patients

  8. Familial Non-Polyposis Colon Cancer (Lynch Syndrome) Leads to Other Cancers

  9. FAP HNPCC Polyps Come in Many Forms

  10. With HNPCC Additional Screening Visits are Necessary

  11. A Preemptive Strike Against Cancer

  12. http://www.hopkins-gi.org/GDL_Disease.aspx https://humana-portal.dnadirect.com/content/physician-site/hereditary-nonpolyposis-colorectal-cancer/index.html http://www.sciencedirect.com/science/article/pii/S1471491402023596 Edelmann, Winfried. "Meiotic Pachytene Arrest in MLH1-Deficient Mice." Cell 85.7 (1996): 1125-134. Print. Pena-Diaz, Javier, and Josef Jiricny. "Mammalian Mismatch Repair: Error Free or Error Prone." Trends in Biochemical Sciences 37.5 (2012): 206-14. Print. http://www.cancernetwork.com/display/article/10165/106278 http://www.gastrolab.net/ng030.htm http://www.ajronline.org/content/186/6/1611.figures-only http://my.clevelandclinic.org/disorders/inherited_colon_cancer/dd_hnpcc.aspx http://www.gen.vcu.edu/GRADUATE/GeneticCounseling Sources

More Related