237 Individuals pre-screened by phone

1. 237 Individuals pre-screened by phone Figure 1S 45 Individuals consented and screened in-person Week 00 • 15 Excluded – Reason(s) for exclusion*: • 4 chronic liver disease • 4 drinking levels below inclusion criteria • 2 psychosis • 2 major current depression • 2 past history of suicide attempt • 1 Post-Traumatic Stress Disorder • 1 current opioid dependence • 1 smoking levels below inclusion criteria • 1 Creatinine levels above inclusion criteria • 1 neurological contraindication to receive baclofen 30 Randomized 15 Randomized to Placebo Week 01 15 Randomized to baclofen 20mg q.i.d. Week 01 • 4 Non completers: • 2 (PI decision due to non-compliance) • 2 (lost contact) • 2 Non completers: • 1 (PI decision due to non-compliance) • 1 (lost contact) 9 of these also enrolled in the 1-day CR study 9 of these also enrolled in the 1-day CR study 13 Completers Week 12 11 Completers Week 12 All 18 completed the 1-day CR study 10 returned for the follow-up Week 16 10 returned for the follow-up Week 16 *some subjects were excluded for multiple reasons