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Immunology Stack

Immunology Stack. Slackers Facts by Mike Ori. Disclaimer. The information represents my understanding only so errors and omissions are probably rampant. It has not been vetted or reviewed by faculty. The source is our class notes.

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Immunology Stack

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  1. Immunology Stack Slackers Facts by Mike Ori

  2. Disclaimer The information represents my understanding only so errors and omissions are probably rampant. It has not been vetted or reviewed by faculty. The source is our class notes. The document can mostly be used forward and backward. I tried to mark questionable stuff with (?). If you want it to look pretty, steal some crayons and go to town. Finally… If you’re a gunner, buck up and do your own work.

  3. B and T Cell progenitor cell

  4. Pre-lymphoid

  5. HSC stem cell markers

  6. CD34(stem cell factor?), CD133

  7. Myeloid progenitor descendents

  8. Granulocytes (Neutrophils, monocytes, Basophils, Eosinophiles) Erythrocytes Platelets

  9. Myeloid Lineage Cytokines

  10. IL-3, IL-5, GM-CSF

  11. Lymphoid Lineage Cytokines

  12. IL-3, IL-7

  13. B Cell Markers

  14. CD19, CD20

  15. Plasma Cell Markers

  16. CD38

  17. Immature B Cell Ig

  18. Early: Heavy chain + psuedo-light chain Late: IgM with heavy and light chains

  19. Mature B Cell Ig

  20. IgM, IgD

  21. Common T-Cell Marker

  22. CD3

  23. T Helper Markers

  24. CD4 CD3 (all T’s)

  25. Cytotoxic T Cell Marker

  26. CD-8 CD-3 (all T’s)

  27. B Cell Maturation Site

  28. Bone marrow

  29. T Cell maturation site

  30. Thymus

  31. Congenital lack of thymus, low T cell count, low IgG (?)

  32. DiGeorge syndrome

  33. T cell receptor subunits

  34. Alpha-beta on CD-4, CD-8 Gamma-delta (not discussed)

  35. Isotype

  36. The major class of an antibody (IgM, IgG, etc)

  37. Allotype

  38. Allelic type changes between Ig of the same isotype.

  39. Idiotope

  40. Antigenic determinant associated with the variable region.

  41. Idiotype

  42. Sum of all idiotopes

  43. Anti-idiotype

  44. The molecule that fits in the idiotype

  45. Domain

  46. A globular region on an antibody consisting of 100-110 amino acids

  47. Hypervariable Region

  48. The area of an antibody subject to recombination and to somatic hypermutation

  49. Complementarity determining region

  50. Antigen

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