1 / 5

Understanding Neuronal Functions: From Genes to Synaptic Transmission and Plasticity

This comprehensive overview delves into the complex world of neuronal functions, highlighting the roles of glial cells, the structure and types of neurons, and the electrical transmission mechanisms. It explores the significance of genes in behavior, including mutations and genetic diseases. The guide also discusses essential concepts such as the ionic basis of membrane potentials, action potential dynamics, and synaptic transmission, analyzing both chemical and electrical signaling. Finally, it covers adult plasticity and learning mechanisms, emphasizing synaptic plasticity and its impact on information processing.

curran-marquez
Télécharger la présentation

Understanding Neuronal Functions: From Genes to Synaptic Transmission and Plasticity

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Review • Intro K2 • functions of glial cells • parts of neurons • types of neurons • electrical transmission of information • stretch reflex • Genes and Behavior K3 • what are genes? • Heredity, kinds of mutations • Per and Tim genes • genes and disease • Cytology K4 • how are neurons like epithelial cells • cytoskeleton • myelin • spines • Synthesis and Trafficking K5 • translation and transcription • protein sorting and packaging • transport and motors

  2. Ion Channels K6 • selectivity • conformational changes • techniques to study • how gated? • Diversity • Membrane potential K7 • ionic basis • ionic concentrations • how created • Nernst and Goldman Equations • techniques to study • circuit descriptions • Passive Signaling K8 • capacitance • ohm’s law • length and time constants • flow of current • myelin

  3. Action potential K9 • current flow • channel kinetics • activation and inactivation • ball and chain • variations on a theme • diversity of firing properties • delayed firing • bursting • accommodation • mechanisms of voltage gating • modulation of firing rate • Synaptic Transmission Overview K10 • Electrical vs. chemical • Neuromuscular Junction K11 • NMJ vs. Central Synapses • End Plate Potential – nACh • Both Na+ and K+

  4. Synaptic Integration K12 • Excitatory vs. Inhibitory • Spatial and temporal summation • Patterns of inputs • Second messengers • Metabotropic vs. Ionotropic • Second messengers amplify but are slower • Second messengers interact with one another • Second messengers can have both short- and long-term effects • Transmitter Release K 14 • Ca++ trigger • Quantal release • Synaptic vesicles – steps and proteins • Many factors regulate amount of release • Neurotransmitters K 15 • Criteria to be considered a transmitter • Peptides vs. small molecule transmitters • synthesis • Corelease • Removal from cleft

  5. Myasthenia Gravis K 16 • Diagnosis • Treatment • Cause • Adult Plasticity and Learning P25 • Synaptic plasticity • Habituation, Sensitization, Association • LTP and LTD in mammalian brain • Plasticity in adult cerebral cortex • Information Processing • Buonomano paper

More Related