1 / 7

The RENAL Replacement Therapy Study

The RENAL Replacement Therapy Study Intensity of Continuous Renal-replacement Therapy in Critically Ill Patients. Reference Bellomo R, Cass A, Cole L, et al . Intensity of continuous renal-replacement therapy in critically ill patients. N Engl J Med. 2009;361:1627–1638. Background

dale-compton
Télécharger la présentation

The RENAL Replacement Therapy Study

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. The RENAL Replacement Therapy Study Intensity of Continuous Renal-replacement Therapy in Critically Ill Patients Reference Bellomo R, Cass A, Cole L, et al. Intensity of continuous renal-replacement therapy in critically ill patients. N Engl J Med. 2009;361:1627–1638.

  2. Background Acute kidney injury warranting continuous renal-replacement therapy (CRRT) is a common finding in intensive care settings. Numerous studies have focused on identifying optimal intensity of CRRT. Bellomo et al. compared two intensities of post-dilution continuous venovenous hemodiafiltration for reductions in 90-day mortality rates among patients with acute kidney injury. This section presents key excerpts of this study.

  3. Aim To identify the effects of two intensities of CRRT on 90-day mortality rates in patients with acute kidney disease.

  4. Methods

  5. Summary of Key Results • There were no significant differences (odds ratio in the higher-intensity group, 1.00; 95% confidence interval [CI]: 0.81–1.23; P=0.99) between groups for all-cause mortality rates within 90-days of randomization (Fig. 1).

  6. • In the high-intensity group, death (within 90 days after randomization) occurred in 44.7% (322 out of 721) patients as compared to 44.7% (332 out of 743) patients in the lower-intensity group. • There were no significant differences between the groups in any of the secondary or tertiary outcomes. • Hypophosphatemia was more common in the higher-intensity group (65%) than in the lower-intensity group (54%). The difference was statistically significant (P<0.001).

  7. Conclusion Higher-intensity and lower-intensity CRRT do not differ significantly in reducing mortality at 90 days in critically ill patients with acute kidney injury. The greater frequency of hypophosphatemia in the higher-intensity treatment group is an expected outcome with more intense treatment. Higher-intensity and lower-intensity CRRT do not differ significantly in reducing mortality at 90 days in critically ill patients with acute kidney injury.

More Related