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Nanotechnology in Medicine NiTi shape memory implant materials and

Nanotechnology in Medicine NiTi shape memory implant materials and Iron Oxide Nanoparticles - Application and Synthesis. Tobias Mogl & Robert Hanke Institute of T echnology - University Linköping Seminar Nanotechnology. Nanotechnology in Medicine

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Nanotechnology in Medicine NiTi shape memory implant materials and

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  1. Nanotechnology in Medicine NiTi shape memory implant materials and Iron Oxide Nanoparticles - Application and Synthesis Tobias Mogl & Robert Hanke Institute ofTechnology - University Linköping Seminar Nanotechnology

  2. Nanotechnology in Medicine PART I: NiTi shape memory implant materials

  3. 1 Motivation body fluid tissue OcclutechFigulla ASD Occluder N ! Ni intolerance ! oxide layer Protege™ GPS™Self-ExpandingStent System

  4. 2CharecterizationoftheOxide Layer NiTi Ni3Ti TiO2 Pt X-rayphotoelectronspectroscopy Rutherford BackscatteringSpectrometry a) A. Undisz, F. Schrempel, W. Wesch, M. Rettenmayr, Mechanism of oxide layer growth during annealing of NiTi, J Biomed Mater Res A (2012), b) G.S. Firstov, R.G. Vitchev, H. Kumar, B. Blanpain, J. Van Humbeeck, Surface oxidation of NiTi shape memory alloy, Biomaterials 23 (2002) 4863-4871.

  5. 3MechanismofOxide Layer Growth NiTi Ni3Ti TiO2 Pt A. Undisz, F. Schrempel, W. Wesch, M. Rettenmayr, Mechanism of oxide layer growth during annealing of NiTi, J Biomed Mater Res A (2012)

  6. 4Heat- Treatment sample induction heating Ni3Ti anode Ar* cathode Pt GDOES - Glow Discharge Optical Emission Spectroscopy source: glow-discharge.com

  7. 5Result NiTi Ni3Ti TiO2 induction heating Pt Bachelorarbeit, Charakterisierung und Einstellung der Oberflächenzusammensetzung von NiTi für die medizinische Anwendung , Friedrich -Schiller Universität Jena, Germany, 2012

  8. Nanotechnology in Medicine PART II: Magnetic Nanoparticles - Application and Synthesis

  9. 1 Motivation source: American Cancer Society, 2013

  10. 2 Conceptofhyperthermia • magnetic Nanoparticles • lock and key principle proteins • induction heating via alternating magnetic field • temperature between 55°C and 60°C for irreversible destroying of tumour cells livescience.com

  11. 3 Synthesis ofNanoparticles - Laser Vaporisation M Ullmann, SK Friedlander, A Schmidt-Ott, “Nanoparticle Formation by Laser Ablation” J. Nanopart. Res.4 (2002) 499-509

  12. 3 Synthesis ofNanoparticles - Laser Vaporisation Prof. Müller, Friedrich Schiller University Jena, Germany

  13. 3 Synthesis ofNanoparticles - LAVA HD´Kurland,JGrabow,GStaupendahl,FAMüller,EMüller,SDutz,MEBellemann:“Magnetic iron oxide nanopowders produced by CO2 laserevaporation - In situ- coating and particle embedding in a ceramic matrix“,J.Magn.Magn.Mater.321(2009)1381–1385

  14. 4CurrentLimitationsofhyperthermia • small particle sizeand size distribution • way of synthesis • homogeneous, specific and non-agglomerated distribution of nanoparticles at the mentioned area • lock and key proteins • amount of nanoparticles • detection of particles in the human body

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