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Nanotechnology in medicine

Nanotechnology in medicine. Applications in cancer. Inigo Arranz & Clara Molinuevo Portal. What is cancer ?. Cells divide and grow uncontrollably, and invade nearby parts of the body. One of the mains causes of death. Therapies nowadays: PROBLEMS: Healthy cells are also killed

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Nanotechnology in medicine

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  1. Nanotechnology in medicine Applications in cancer Inigo Arranz & Clara Molinuevo Portal

  2. Whatiscancer? • Cells divide and grow uncontrollably, and invade nearby parts of the body. • One of the mains causes of death. • Therapies nowadays: • PROBLEMS: • Healthy cells are also killed • Invasive treatment • Lots of adverse side effects: nausea, hair-loss, fatigue...

  3. How can nanotechnologyhelpus? • Build new tools that are smaller than cells. • Opportunity to attack cancer cells at the cellular and genetic level. • So precise that doctors will be able to design individual treatments. • Less recovery and hospital time. NANOTECHNOLOGY IS CHANGING THE WAY WE LOOK AT CANCER

  4. Applications in cancer? • Drug delivery Chemotherapy kills tumor cells and healthy cells. Nanocarriers: deliver medication directly to the tumor. • Killing tumor cells Thanks to gold nanoshells.

  5. GoldNanoshells • Sphericalnanoparticlesconsisting of a dielectriccore and a metallicshell (120 nmwidth)

  6. How do theywork? • Patientreceivesnanoshellsintravenously • Nanoshellsbindtocancercellsbyantigen-antibodyinteraction • Doctorsshinethetumourwithinfrared light tokillcancercells Whydoesinfrared light killthecells?

  7. Infrared light

  8. How do theywork?

  9. State of the art • Jennifer West applicatednanoshells to cancer treatment. • Naomi Halas invented the nanoshells in 2003. • Good results were obtained in vitro and in vivo with mice. • Nanospectra is doing clinical trials for head, neck, lung and prostate cancer since 2008 in different hospitals in the USA.

  10. Referencelist • Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance L. R. Hirsch, R. J. Stafford, J. A. Bankson, S. R. Sershen, B. Rivera, R. E. Price, J. D. Hazle, N. J. Halas, and J. L. West • NationalCancerInstitute Alliance forNanotechnology in Cancer (http://nano.cancer.gov/) • WorldHealthOrganization (http://www.who.int/en/) • Youtube: Nanoshell Therapy: Using Gold to Fight Cancer (http://www.youtube.com/watch?v=AWtdkPOhNfE) • Rice University News (http://news.rice.edu/2012/11/02/nanoshell-therapy-to-be-tested-in-lung-cancer-clinical-trial/) • ScienceDaily (http://www.sciencedaily.com/releases/2004/06/040622020433.htm)

  11. Questions? Nanotechnology in medicine Applications in cancer Inigo Arranz & Clara Molinuevo Portal

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