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No Disease – Ever! Unlocking The Power of Oxygen

No Disease – Ever! Unlocking The Power of Oxygen. Third Congress, March 2014. Frank Shallenberger, MD, HMD Carson City, NV. “The world belongs to the energetic.” Ralph Waldo Emerson Essayist & poet (1803 - 1882). Resources. Bursting With Energy The Type 2 Diabetes Breakthrough

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No Disease – Ever! Unlocking The Power of Oxygen

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  1. No Disease – Ever!Unlocking The Power of Oxygen Third Congress, March 2014 Frank Shallenberger, MD, HMD Carson City, NV

  2. “The world belongs to the energetic.” Ralph Waldo EmersonEssayist & poet (1803 - 1882)

  3. Resources • Bursting With Energy • The Type 2 Diabetes Breakthrough • The Principles and Applications of Ozone Therapy • www.antiagingmedicine.com

  4. No Disease-Ever! • Oxygen is the most important nutrient that we take in. But just because we take it in does not mean that we are using it efficiently. • Oxygen Utilization (OU) is the term I coined to refer to how efficiently our body processes oxygen. • The most important factor determining your risk of disease and rate of aging is oxygen utilization.  • I have patented and developed a system for measuring oxygen utilization which I have been using for over ten years.

  5. No Disease-Ever! • In that time I have not seen one case of cancer or any other disease in a person with optimal oxygen utilization. • Nor have I ever seen any disease develop in a person with optimal oxygen utilization no matter what their age. • This is a fantastic observation, and suggests that anyone who is able to maintain optimum oxygen utilization during their lifetime will be immune to disease across the board. 

  6. Measuring Oxygen Utilization • FDA approved pulmonary gas analyzer. • Computer driven exercise ergometer. • Computer software to sort and analyze the breath by breath data. • Test takes about 45 minutes. • Completely safe • Athletes – VO2 max

  7. Bio-Energy Testing® • A software system uses the data to calculate oxygen utilization based upon how much oxygen is consumed and how much carbon dioxide is produced at rest and during exercise. • Oxygen Utilization is a function of how much oxygen is consumed relative to carbon dioxide produced. • Other measurements: Metabolic Rate, Fat Burning Rate, Resting Fat Metabolism, Heart Function, Lung Function, Functional Strength, Exercise Data, Diet Data.

  8. The Cost of Being Sick • Boston Globe: “Retired couples may need $240,000 for health care”. By Mark Jewell. The Associated Press, May 9, 2012 • “Couples who retire this year can expect to spend an average of $240,000 on out-of-pocket medical expenses before they die.” • Life expectancy of 85 for women and 82 for men. • These expenses are above and beyond what Medicare and insurance pays. • And they don’t take into account dental expenses or long term care which could easily add up to thousands more.

  9. The Cost of Being Well • Testing, Supplements, and hormones = $135/month • Exercise = $2000 lifetime • Food = $0.00 • Detoxification = $1000/year • Circulation - $200/year • $2,820/year per person • $56,400 per woman and 47,940 per man • Total = $104,340

  10. Can It Really Be Done? • There are an estimated 80,000 people in the United States who are more than 100 years old. • Virtually all of these people have been completely free of disease all their lives. • I have patients in their 80’s who have the oxygen utilization of 35 year olds.

  11. Can It Really Be Done? • Because of genetics, not everyone will be able to have optimal oxygen utilization. • But everyone is able to significantly decrease their risk by improving their oxygen utilization. • In an ideal world everyone would have their oxygen utilization measured every 1-2 years. • This lecture will summarize what needs to be done in order to optimize oxygen utilization

  12. Mitochondrial Facts • Metabolically active cells contain thousands of mitochondria, which make up ∼40% of the entire cell. There are said to be 10 million billion mitochondria in an adult human (i.e. ∼10% of our body weight). • Mitochondria are not static. According to how you live and the balance of your hormones they are in constant movement within cells, and are constantly changing in size, number and mass.

  13. Mitochondrial Facts • Mitochondria divide during mitosis, providing daughter cells with a normal complement of mitochondria. Mitochondria also proliferate during weight training and aerobic exercise. • The number of mitochondria is controlled by T3, which specifically induces mitochondrial division  • You get your mitochondria from your mom.

  14. Mitochondrial Facts • Genetic forms of obesity including diabetes have defective mitochondrial activity. • This defect leads to a higher ratio of weight gain to food intake. • Experimental evidence indicates that increasing mitochondrial activity in these patients will cure them.

  15. Oxygen Utilization Fat Glucose E Lungs Heart Circulation OU Oxygen Free Radicals Hormones, Nutrients, Toxins, Stress

  16. Organ Function Elimination Senses Oxygen Utilization Hormones Repair Digestion Thoughts Reproduction

  17. What Is Health? • Not the absence of symptoms. • Not the absence of disease. • Not the absence of abnormal tests. • Not the absence of anything – health is the presence of something – Optimum Oxygen Utilization.

  18. Every single aspect of healthy living exerts its effects by improving oxygen utilization

  19. Decreased oxygen utilization only happens in old folks, right?WRONG!It commonly starts in young, otherwise healthy people.

  20. Published in Townsend Letter • 50 Subjects: Randomly selected as they presented to the clinics, 20-40 y/o, asymptomatic, “health conscious”, Carson City, Los Angeles, Grand Junction, and Singapore. • 54% (27) had normal oxygen utilization. • 46% (23) had decreased oxygen utilization.

  21. Published in Townsend Letter • 36% (18) had < 90% of predicted oxygen utilization. • 26% (13) had < 80% of predicted oxygen utilization. • 12% (6) had < 60% of predicted oxygen utilization, and fell within the diagnostic category of severe dysfunction.

  22. Outline Aging and thediseases of aging are causedprimarilybydecreasedoxygenutilization. Decreasedoxygenutilization leads totheexcessive free radicalsthatresult in acceleratedaging and disease. Decreasedoxygenutilizationis a unifyngprinciple. Itiscausedbymanyfactors. DecreasedoxygenutilizationexertsitsnegativeeffectsbydecreasingtheNAD/NADH ratio. The keytohealthistomaximizeoxygenutilizationbyeliminatingordecreasingtheeffect of thesefactors.

  23. 1. Aging and thediseases of aging are causedprimarilybydecreasedoxygenutilization

  24. Oxygen – The Forgotten Nutrient • The most critical nutrient. • It’s not what you take in, it’s what you utilize. • The difference between you at 20 and you at 70 is your level of oxygen utilization.

  25. Aging and Oxygen Utilization Nothing is as consistent and as predictable as the gradual, linear decline in oxygen utilizationseen in all aging populations. It starts early!

  26. Meta-analysis of the age associated decline in maximal aerobic capacity in men: relation to training status. • Wilson & Tanaka, Am. J. Physiol. Heart Circ. Physiol. Vol. 278: 829-834, 2000 • “Maximal aerobic capacity is an independent risk factor for cardiovascular disease, cognitive dysfunction, and all cause mortality.” • Even highly trained marathon runners show a decrease in oxygen utilization with age. Unlike all of the other parameters of aging, it cannot be trained away.

  27. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Trifunovic A, Wredenberg A, et al. Nature. 2004 May 27;429(6990):417-23. • Mice are genetically altered to develop defective oxygen utilization over their lifespan. • Significantly reduced lifespan. • Premature onset of age-related disorders such as lean body mass loss, alopecia, kyphosis, anemia, osteoporosis, reduced fertility, and cardiomegaly. • “These results provide a causative link between decreased oxygen utilization and aging.”

  28. Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer. • Examined a group of mice and measured their resting oxygen utilization. Then they simply noted how long they lived. • All mice were treated the same. The only differences were their natural genetic differences in oxygen utilization. • Mice in the top 25% of oxygen utilization lived 36% longerthan mice in the low 25%. Speakman JR, Talbot DA, et al. Aging Cell. 2004 Jun;3(3):87-95.

  29. Oxygen Utilization and Disease • Varanasi SS, Francis RM, et al. Mitochondrial DNA deletion associated oxidative stress and severe male osteoporosis. Osteoporos Int. 1999;10(2):143-9. • Liang FQ, Godley BF. Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration. Exp Eye Res. 2003 Apr;76(4):397-403.

  30. Oxygen Utilization and Disease • Patwari P, Lee RT. Thioredoxins, mitochondria, and hypertension. Am J Pathol. 2007 Mar;170(3):805-8. • Eerola E, Pulkki K, et al. Abnormal mitochondria in cultured synovial fibroblasts in rheumatoid and reactive arthritis? Br J Rheumatol. 1988;27 Suppl 2:128-31.

  31. Oxygen Utilization and Disease • Modica-Napolitano JS, Kulawiec M, et al. Mitochondria and human cancer. Curr Mol Med. 2007 Feb;7(1):121-31.  • GerbitzKD, Gempel K, Brdiczka D. Mitochondria and diabetes. Genetic, biochemical, and clinical implications of the cellular energy circuit. Diabetes. 1996 Feb;45(2):113-26.

  32. Oxygen Utilization and Disease • Biskup S, Moore DJ. Detrimental deletions: mitochondria, aging and Parkinson'sdisease.Bioessays. 2006 Oct;28(10):963-7. • Moreira PI, Cardoso SM, et al. The key role of mitochondria in Alzheimer's disease. J Alzheimers Dis. 2006 Jul;9(2):101-10.

  33. Oxygen Utilization and Disease • Tsutsui H. Oxidative stress in heart failure: the role of mitochondria.Intern Med. 2001 Dec;40(12):1177-82. •  Marin-Garcia J, GoldenthalMJ. Heart mitochondria signaling pathways: appraisal of an emerging field. J Mol Med. 2004 Sep;82(9):565-78

  34. 2. Decreasedoxygenutilization leads totheexcessive free radicalsthatresult in acceleratedaging and disease.

  35. Hypoxia • Generates excessive free radicals. • Deprives cells of vital functions including repair mechanisms, membrane polarization, and enzyme synthesis. This includes the synthesis of anti-oxidant enzymes. • Destroys mitochondria.

  36. Decreased Oxygen UtilizationIs The Metabolic EquivalentofHypoxia “Functional Hypoxia”

  37. Free Radical Damage is Caused By “Excessive” Radical Activity Secondary to Decreased Oxygen Utilization “Decreased oxygen utilization is toxic to the cell by exacerbating free radical generation in membranes housing electron transfer assemblies.” • Antioxidant Adaptation Levine & Kidd • Decreased oxygen utilization accelerates free • radical formation, while exhausting anti- • oxidant buffering capacity.

  38. Decreased Oxygen Utilization Decreased Free Radical Buffering Increased Free Radical Formation Mitochondrial Decay Degenerative Disease Aging

  39. “Oxidative Damage and Mitochondrial Decay in Aging.” Shigenaga MK, Hagen TM, Ames BN Proc. Natl. Acad. Sci. USA Vol. 91, 10771-78, Nov. 1994 • “Oxidants generated by mitochondria appear to be the major source of oxidative lesions that accumulate with age.” • “These lesions cause the age related deficits in mitochondrial function which are associated with the generalized physiological decline known as aging.” • These oxidative lesions are caused by reduced oxygen utilization.

  40. Are Free Radicals Bad?

  41. “The essential requirement for superoxide radical and nitric oxide formation for physiological functioning and healthy aging” LinnaneAW, Kios M, Vitetta L. Mitochondrion, 2007, Vol. 7, Nos. 1-2

  42. “Contrary to the dogma that superoxide anion and hydrogen peroxide formation are highly deleterious to cell function and healthy aging, we suggest this premise is flawed. Superoxide anion and hydrogen peroxide formation are essential to normal cellular function. Superoxide anion and nitric oxide play an intrinsic role in the regulated ordered turnover of proteins, rather than randomly cause protein damage and inactivation. The proposition that metabolic free radical formation is unequivocally deleterious to cell function is rebutted. The concept that a dietary supplement of high concentrations of small-molecule anti-oxidants is a prophylactic/amelioration therapy for the aging process and age associated diseases is questioned as to its clinical validity.”

  43. “Oxidative Damage and Mitochondrial Decay in Aging.” Shigenaga MK, Hagen TM, Ames BN Proc. Natl. Acad. Sci. USA Vol. 91, 10771-78, Nov. 1994 • “Oxidants generated by mitochondria appear to be the major source of oxidative lesions that accumulate with age.” • “These lesions cause the age related deficits in mitochondrial function which are associated with the generalized physiological decline known as aging.” • These oxidative lesions are caused by reduced oxygen utilization.

  44. “As I see it every day you do one of two things: build health or produce disease in yourself.” Adelle Davis Author and nutritional pioneer

  45. 3. Decreasedoxygenutilizationiscausedby: Diet, Hormonal Deficiencies, NutritionalDeficiencies, Smoking, Drugs, Toxins, DecreasedCirculation, DecreasedLungFunction, Inflammation, Stress, DecreasedFitness

  46. Diet • Carbs!!!! • GMO? • Low Fiber • Processed foods • Excessive calories

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