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PATHOBIOLOGY OF THE LABORATORY MOUSE

PATHOBIOLOGY OF THE LABORATORY MOUSE. Tier 1A. THE MOUSE AS A BIOLOGICAL MODEL. 1. History of the Laboratory Mouse 2. Regulations Governing Use of Mice 3. Maintaining a Healthy Mouse Colony. By S.W. Barthold. HISTOLOGIC TECHNIQUES. GROSS ANATOMY. 1. Genitourinary 2. Musculoskeletal

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PATHOBIOLOGY OF THE LABORATORY MOUSE

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  1. PATHOBIOLOGY OF THE LABORATORY MOUSE Tier 1A

  2. THE MOUSE AS A BIOLOGICAL MODEL 1. History of the Laboratory Mouse 2. Regulations Governing Use of Mice 3. Maintaining a Healthy Mouse Colony By S.W. Barthold

  3. HISTOLOGIC TECHNIQUES

  4. GROSS ANATOMY

  5. 1. Genitourinary 2. Musculoskeletal 3. Cardiovascular 4. Respiratory 5. Digestive 6. Lymphoreticular 7. Endocrine/Exocrine 8. Integumentary 9. Nervous 10.Sensory NORMAL MOUSE MICROANATOMY

  6. PATHOLOGIC PROCESSES • Introduction to Pathological Processes • Cell Injury and Cell Death • Repair • Inflammation • Hemodynamic Disorders • Neoplasia

  7. CLINICAL PATHOLOGY –CLINICAL CHEMISTRY

  8. PATHOBIOLOGY OF THE LABORATORY MOUSE Tier 1B

  9. THE UNIQUE LABORATORY MOUSE TIER 1B • Mouse Nomenclature and Genetic Terminology SW Barthold, DVM, PhD • Immunobiology of the Laboratory Mouse Nicole Baumgarth, DVM, PhD • Unique Characteristics of the Laboratory Mouse RD Cardiff, MD, PhD • Normal Mouse Embryology Jerrold M Ward, DVM, PhD • Reproductive Cycle: Estrus Rashida Latham, PhD, RD Cardiff, MD, PhD • Mouse Skin and Hair Cycle Donna F. Kusewitt, DVM, PhD

  10. “How To” Techniques for Studying Mouse Pathobiology • Gross Descriptive Terminology Stephen Griffey, DVM, PhD • ICIARC: Gross Tissue Identification RD Cardiff, MD, PhD • ICMIAD: Microscopic Lesion Identification RD Cardiff, MD. PhD • How to Make GEM A. Borowsky, MD and D. Kusewitt, DVM, PhD • Abnormal Embryology in GEM JM Ward, DVM, PhD • Basic Surgical Techniques Charles Daniels, PhD • Light and Electron Microscopy RJ Munn, MS • Experimental Design RD Cardiff, MD, PhD

  11. PATHOBIOLOGY OF THE LABORATORY MOUSE 1. Infectious Diseases of the Laboratory Mouse S. Barthold, DVM, PhD, CH Miller, PhD, R Munn, MS 2. Background Pathology Donna Kusewitt, DVM, PhD 3. Spontaneous Tumors RD Cardiff, MD, PhD

  12. PATHOBIOLOGY OF THE GENETICALLY ENGINEERED MOUSE • GEM Tumor Pathology: How Genes Control Tumor Phenotype • RD Cardiff, MD, PhD • Classic GEM Tumors RD Cardiff, MD, PhD • Immunodeficient Mice Oded Foreman, DVM and DF Kusewitt, DVM, PhD

  13. MODULES UNDER DEVELOPMENT 1. Lymphoma: A Study in Comparative Pathology V.Valli, DVM, PhD 2. Small Animal Imaging D. Rowland, PhD 3. Metabolic Diseases: Diabetes & Obesity C. Braydon, DVM 4. Using Stem Cells K. Erickson, PhD 5. Male Murine Fertility and Reproduction 6. Advanced Microbiology S. Barthold, DVM, PhD 7. Comparative Pathology of Viral Infections M. Gardner, MD 8. Models of Progression to Cancer A.Borowsky, MD 9. Toxicology: Three modules: G. Cantor, MD, R. Maronpot, PhD and N. Dybdal, DVM

  14. Modules Promised To CGP 1. Pathology of the Eye 2. Pathology of the Mouth and Teeth 3. Degenerative Nerve Disease

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