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Synaptic Transmission. Electrical & Chemical Synapses. Events Involved in Transmission at a Chemical Synapse. Local Recycling of Synaptic Vesicles in Presynaptic Terminals. Presynaptic Proteins Implicated in Neurotransmitter Release. Molecular Mechanisms of Neurotransmitter Release.
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Local Recycling of Synaptic Vesicles in Presynaptic Terminals
Diseases that Affect the Presynaptic Terminal Several congenital forms result in fewer or smaller vesicles = less transmitter Lambert-Eaton myasthenic syndrome = Ab mediated
Toxins That Affect Transmitter Release Toxins cleave SNAREs Tetanus affects inhibitory interneurons = hyperexcitation of muscles Botulism paralyzes peripheral muscles = do not contract
Toxins That Affect Transmitter Release Black widow venom = exocytosis w/o calcium Binds to CL1 and neurexin, neurexin binds to synaptotagmin
Diseases Caused by Altered Ion Channels FHM = familial hemiplegic migraine EA2 = episodic ataxia CSNB = congenital stationary night blindness