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Objectives. To review the etiology and pathophysiology of gout To recognize predisposing factors for goutTo review diagnostic criteria and evaluation for goutTo select appropriate treatment for a patient presenting with gout.. Gout. IntroductionEtiology ? Primary vs secondarygoutEpidemiology ?
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1. Diagnosis and Management of Gout Sadeq AL-Shmesawy
2. Objectives To review the etiology and pathophysiology of gout
To recognize predisposing factors for gout
To review diagnostic criteria and evaluation for gout
To select appropriate treatment for a patient presenting with gout.
3. Gout Introduction
Etiology Primary vs secondarygout
Epidemiology Age, gender and race
Pathophysiology
Predisposing factors
Associated conditions
Presentation History, PE, Lab, and Radiology work-up
Differential Diagnosis
Treatment Summary pharmacologic Non-pharmacologic.
4. Definition Gout is a heterogeneous disorder that results in the deposition of uric acid salts and crystals in and around joints and soft tissues or crystallization of uric acid in urinary tract.
Uric acid is the normal end product of the degradation of purine compounds.
- Major route of disposal is renal excretion
- Humans lack the enzyme uricase to break down uric acid into more soluble form.
Metabolic Disorder underlying gout is hyperuricemia.
- Define as 2 SD above mean usually 7.0 mg/dL. This concentration is about the limit of solubility for (monosodium urate) MSU in plasma. At higher levels, the MSU is more likely to precipitate in tissues.