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Monitoring Changes in Cerebral Hemodynamics following Optogenetic Activation

Monitoring Changes in Cerebral Hemodynamics following Optogenetic Activation. Seth Frye, Farid Atry , Alana Soehartono , Tom Richner , Sarah Brodnick , Justin Williams, Ramin Pashaie CEAS Poster Presentation Spring 2014. Optical Coherence Tomography.

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Monitoring Changes in Cerebral Hemodynamics following Optogenetic Activation

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  1. Monitoring Changes in Cerebral Hemodynamics following Optogenetic Activation Seth Frye, Farid Atry, AlanaSoehartono, TomRichner, Sarah Brodnick, Justin Williams, RaminPashaie CEAS Poster Presentation Spring 2014

  2. Optical Coherence Tomography • Axial scan (A-scan) measures reflectivity at single point on sample • Transverse scan (B-scan) collects multiple A-scans to create cross sectional image • Stack transverse scans to create 3D image of sample Fujimoto. “Optical coherence tomography for ultrahigh resolution in vivo imaging.” Nature Biotechnology, Volume 21 , Number 11. November 2003.

  3. Angiography and Velocity Profile • Mouse Cortex Brightfield image • Projection of Angiogram and velocity profile 0.1 mm 0.1 mm 0.1 mm

  4. Results -7 mm/s -7 mm/s Velocity Velocity +7 mm/s +7 mm/s • Wide field hemodynamic effects of Optogenetic stimulation • Dilation of blood vessels and Increase in blood velocity observed 0.1 mm 0.1 mm

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