The Role of ApoE and ApoD in the Hippocampus and Cerebral Cortex Functionality

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This study explores the involvement of Apolipoprotein E (ApoE) and Apolipoprotein D (ApoD) in key regions of the brain, specifically the hippocampus and isocortex (cerebral cortex). We focus on various areas within these regions, including CA1, CA2, CA3, and the dentate gyrus (DG). Additionally, the analysis encompasses the cerebellar cortex and choroid plexus. Understanding the functions and interactions of ApoE and ApoD may provide insights into cognitive processes and potential neurodegenerative conditions.

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Feb 19, 2026

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The Role of ApoE and ApoD in the Hippocampus and Cerebral Cortex Functionality

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A ApoE ApoD B. Hippocampus C. Cerebral cortex (isocortex) I I II CA1 CA1 II III III IV CA2 CA2 V IV VI V VI CA3 CA3 DG DG CC CC ApoD ApoD ApoE ApoE E. Cerebellar cortex D. Plexus choroid ML ML PC PC PL PL GL GL ApoD ApoD ApoE ApoE Fig. S2