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Analysis of BrdU Incorporation and Protein Expression in LNCaP and LAPC4 Cells Post-Irradiation

This figure illustrates the effects of ionizing radiation (IR) on BrdU incorporation in LNCaP and LAPC4 prostate cancer cell lines, comparing various conditions including shCon and shRB knockdowns. It includes data across multiple time points (0.25, 2, 6, 24 hours post-IR) and evaluates the levels of key proteins such as p21Cip1, p53, and CDC25a alongside LaminB and CDk2. This analysis provides insights into cellular responses to damage and the role of retinoblastoma protein (RB) in checkpoint control after DNA damage induced by radiation.

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Analysis of BrdU Incorporation and Protein Expression in LNCaP and LAPC4 Cells Post-Irradiation

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  1. Supplemental Figure 1. 0 Gy IR 10 Gy IR E LNCaP shCon LNCaP shRB LNCaP shCon LNCaP shRB C A LNCaP 6 D B Post-IR (hrs) LAPC4 LNCaP Post-IR (hrs) LAPC4 shRB shCon shRB shCon Post-IR (hrs) Relative BrdU (Normalized to Control) Relative BrdU (Normalized to Control) LNCaP 0.25 2 6 24 0.25 2 6 24 0.25 2 6 24 .25 2 6 24 24 p21Cip1 p21Cip1 shCon shRB p53 p53 0 Gy IR 10 Gy IR LaminB LaminB LAPC4 shCon LAPC4P shRB LAPC4 shCon LAPC4 shRB 48 6 48 6 Post-IR (hrs) Lane 1 2 3 4 5 6 7 8 Post-IR (hrs) Lane 1 2 3 4 5 6 7 8 F 6 Post-IR (hrs) 24 G LAPC4 CDC25a shCon shRB CDk2 No IR CDC25a LaminB CDk2 IR 10 Gy LaminB 1 2 3 4 Lane

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