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Yizhou Jiang, Yi Wang, Zijie Su, Ling Yang, Weiwei Guo, Ji Zuo

Synergistic Induction of Apoptosis in HeLa Cells by the Proteasome Inhibitor Bortezomib and Histone Deacetylase Inhibitor SAHA. Yizhou Jiang, Yi Wang, Zijie Su, Ling Yang, Weiwei Guo, Ji Zuo. INTRODUCTION. Bortezomib: Proteasome inhibitor

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Yizhou Jiang, Yi Wang, Zijie Su, Ling Yang, Weiwei Guo, Ji Zuo

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  1. Synergistic Induction of Apoptosis in HeLa Cells by the Proteasome Inhibitor Bortezomib and Histone Deacetylase Inhibitor SAHA Yizhou Jiang, Yi Wang, Zijie Su, Ling Yang, Weiwei Guo, Ji Zuo

  2. INTRODUCTION • Bortezomib: Proteasome inhibitor • Suberoylanilide hydroxamic, SAHA: Histone deacetylase inhibitor • HeLa cells

  3. Combination of Bortezomib and SAHA Inhibits HeLa Cell Growth b a c

  4. Combination of Bortezomib and SAHA Induces HeLa Cell Apoptosis a c d b * * * * * *

  5. Combination of Bortezomib and SAHA Enhances Bax/bcl-2 Ratio a c A B C D b d * * A A B B * * C C

  6. Combination of Bortezomib and SAHA Inhibits NF-kB Nuclear Translocation and Downregulates Akt/p-Akt a b

  7. Akt and NF-kB Signaling Pathways

  8. CONCLUSION Bortezomib + SAHA Synergistic Induction of Apoptosis In HeLa Promising Rationale for Treating Cervical Cancer Akt, p-Akt, NF-kB↓; bax/bcl-2↑; caspase-3↑

  9. THANK YOU

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