1 / 24

Prostate SPORE Informatics: Short term & Long term

Prostate SPORE Informatics: Short term & Long term. Buddy Dennis, UCLA School of Medicine caBIG Annual Meeting June 2008. Supporting prospective, multicenter data collection, and federated retrospective inquires. Build and manage an infrastructure to support collaborative investigations.

diane
Télécharger la présentation

Prostate SPORE Informatics: Short term & Long term

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Prostate SPOREInformatics: Short term & Long term Buddy Dennis, UCLA School of Medicine caBIG Annual Meeting June 2008

  2. Supporting prospective, multicenter data collection, and federated retrospective inquires. Build and manage an infrastructure to support collaborative investigations. Support the InterSPORE Prostate Biomarker Study (IPBS prospective component). Add capabilities to allow investigators to conduct searches across the participating SPORE sites (retrospective inquires).

  3. IPBS prospective requirements • Patients accrued at each SPORE site • Clinical and demographics data collected • Tissue and blood samples (biomaterials) collected and annotations recorded • Periodically batches of biomaterials are sent to central pathology • Central pathology collates and sends out biomaterials to biomarker labs • Patients are followed for 5 years after treatment

  4. ‘Short-term’ Decision • pTracker - Opensource- development package (~CTMS) • Centrally managed, shared instance • Collaborative development CRF refined as paper forms • Electronic CRFs built in pTracker • Workflow in pTracker implemented from the protocol requirements documents

  5. Case Report Forms (data elements) • Pt Enrolllment: • Accrual form (6) • Pt Questionnaire (~130) • Pt Data from Chart (~20) • QoL (6) • Biospy &Serum Collection: • Blood form (~25) • Tissue form(~25) • Primary Treatment • Primary Txt form (34) • Post Treatment Followup • Blood form (~25) • Pt … (41) • QoL (6)

  6. Patient Accrual • Specimen shipping & Tracking to Central pathology • Specimen Inventory • Specimen shipping and tracking to Biomarker labs. • Shared Documents: • Printable CRFs • MTAs • SOPs … • Directory • Status Reports

  7. pTracker - IPBS current prospective solution Central server with site-specific logins. Supports all aspects of the IPBS prospective study. Protects each sites data. Manages shipping of specimens. In full operation. Biomarker annotations not yet specified.

  8. Tissue Banks and Pathology Tools WS caTissue Suite 1.0 installs at most SPORE site (still struggling with production-level setups). Customized to accommodate IPBS-specific data- Dynamic extensions. Next version (1.1) due in the Fall 2008 with more support for things we need to do.

  9. pTracker  caTissue Data collected by pTracker exported as XML and then imported into each caTissue suite DB. Only data from patients accrued at a SPORE site is migrated. Data migration is accomplished with XcaCORE tool on pTracker server.

  10. Making data available Why go to all the bother if all we are putting into caTissue Suite is IPBS prospective data? A federation of caTissue databases becomes useful and valuable as more data are made available to each other. Each Prostate SPORE deciding what (& how) data should go into caTissue at that site?

  11. An infrastructure for supporting Inter-SPORE research utilizing caBIG technologies

  12. Baylor David Steffen Lauren Becnel Dana Farber Jomol Mathew William Oh Erica Jones Devon Henor Fred Hutch Russ Kaake Steve Griggs Johns Hopkins Bruce Trock James D. Morgan Helen Fedor Michelle Brotzman Mayo Clinic Mathieu Weipert Darren Riehle Wilma Lingle Maureen Lemens Marcia Goodmanson MD Anderson Randy Milikan Jeff Jin Zerong Jiang Michigan Javed Siddiqui Terry Barret Radhika Varambally MSKCC Kevin Regan Wes Fang Kai Lin Paul Fearn Northwestern Warren Kibbe Dong Fu Julie Zhu UCLA Buddy Dennis Andy Helsley UCSF Jenny Broering Katrina Carrion Hazel Diaz Sudeep Basnet Paul Norris Booz Allen Juergen Klenk Ken Jones Becca Reilly John Dorries Vikram Purhit Miguel Buddle Edmond NCI Ian Fore Wendy Patterson Andrew Hruszkewycz Shen Liming Washington University Rakesh Nagarajan Mark Watson Srikanth Adiga Porrnima Govindrao Sachin Lale

  13. Questions

More Related