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Understanding Cortical Structures and Treatment of Nausea & Vomiting

Explore the connection between cortical structures like pain and fear and the management of nausea and vomiting through drugs like benzodiazepines and steroids. Learn about the role of GABA, chemoreceptor trigger zone, and antiemetic treatments.

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Understanding Cortical Structures and Treatment of Nausea & Vomiting

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  1. Cortical structures eg pain, fear, sights, smells, raised ICP: Benzodiazepines & steroids ?GABA Vomiting centre levomepromazine Hyoscine Cyclizine* M H1 5-HT2 Vestibular Apparatus Levomepromazine Cyclizine* Hyoscine Chemoreceptor trigger zone (CTZ) eg drugs, toxins, biochemical upset Haloperidol* Metoclopramide Levomepromazine H1 M D25-HT3M Autonomic nervous system (vagus nerve) eg pharyngeal irritation, gastric/bowel obstruction, constipation Levomepromazine Metoclopramide* Ondansetron N&V Key: Site Cause Antiemetic [Highest receptor affinity top] [*usual first line] J Adam 2006 M D2 5-HT3 Receptors

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