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Analysis of Isoform Variability and Splice Patterns Across Populations

This study examines the diversity of isoforms and their splice-delta patterns across various populations. We analyze the differences in splicing from major expressed splice patterns, noting key characteristics like the farStart (spliced reads starting before the first exon) and farEnd (spliced reads extending beyond the last exon). Multiple splice junction categories are identified, revealing significant patterns, including steep decreases in isoform presence and flat decreases at splice sites. This research enhances our understanding of alternative splicing and its implications in gene expression.

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Analysis of Isoform Variability and Splice Patterns Across Populations

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  1. Isoforms / startpointfor all populations numberofisoforms per startpoint for all populations

  2. splice-deltas (i.e. difference [in bp] from the major expressed splice-pattern)

  3. farStart: spliced read that starts before the first exon farEnd: spliced read that extends beyond the last exon a splice-junction may be in multiple categories

  4. steep decrease (50 patterns for 76.26% of all splice-sites)

  5. flat decrease (100 patterns for 73.72% of all splice-sites)

  6. Identification of variable splice-sites

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