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NIA LOAD Genetics Initiative

NIA LOAD Genetics Initiative. Progress Report 2007: NCRAD and LOAD Update Kelley Faber, MS, CCRC National Cell Repository for Alzheimer’s Disease. LOAD Recruitment. Family referral from NCRAD to Sites: 2003: 131 Families 2004: 112 Families 2005: 28 Families 2006: 37 Families

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NIA LOAD Genetics Initiative

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  1. NIA LOAD Genetics Initiative Progress Report 2007: NCRAD and LOAD Update Kelley Faber, MS, CCRC National Cell Repository for Alzheimer’s Disease

  2. LOAD Recruitment • Family referral from NCRAD to Sites: • 2003: 131 Families • 2004: 112 Families • 2005: 28 Families • 2006: 37 Families • 2007: 9 Families so far… • Common recruitment sources • Internet, Alzheimer’s Association, clinicaltrials.gov • NCRAD/Columbia plan to attend several small regional conferences as well as Dementia Care Conference in Chicago, IL

  3. NCRAD Recruitment • Continue to recruit new families • Good option for families who fail to meet LOAD criteria (not sibs, no 3rd person, not over 60) • 2+ living with early or late onset AD, related dementia • Qualifying families should contact NCRAD directly • Almost 900 families currently enrolled

  4. LOAD Update • Qualifying Families and Controls • April 2007 data call added 24 new qualifying families! • We are now up to 427 total • We have 590 control samples Keep Up The Good Work!!

  5. Pedigree Review • Every 6 months prior to data call and data cleaning • Make corrections prior to data submission • Each site asked to review updated list of potentially “completed” families • Both qualifying and dead end families • NCRAD will plot families for each site from MDS • Fax or FedEx to site for verification

  6. Pedigree Review • After site verifies family structure, samples will be screened in IU lab • If errors reported: • NCRAD verifies that sample IDs are correct • Review data set and pedigree submitted by site • Contact site to validate data • Investigate sources of lab error

  7. Pedigree Review • First pedigree review April 2007 • Received pedigrees from 12 sites • Sending 43 new qualifying and completed families to lab for fingerprinting • Dead End families • NCRAD will not release samples to investigators until pedigree review process is complete!!

  8. LOAD/NCRAD Quality Checks Complete study visits Family recruited Proband ascertained Send blood to NCRAD NCRAD confirms family structure Database & submit MDS to NCRAD NCRAD reviews MDS Family complete

  9. Sample Requests • Researchers currently requesting samples from NCRAD and LOAD families • NCRAD pedigrees currently online at www.ncrad.org • LOAD pedigrees for CIDR families are coming online!!!

  10. Sample Requests • To further promote NCRAD and its resources, staff will be at the Alzheimer’s Association International Conference on Prevention • NCRAD booth in exhibit hall

  11. Sample Requests • Fingerprinting all samples on the way out of lab to researcher • Started charging cost recovery fee for requested samples • LOAD investigators will continue to receive a single free aliquot of 25ug of DNA for those samples they have collected

  12. NCRAD Lab Update • Biomek 3000 robot • Reduce costs • Reduce errors • Mass produce • New database built from scratch • Better tracking • Cleaning data

  13. Summary • Pedigree review important to increase available families and samples • New sample request process • Hope to gain more qualifying families with follow-up

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