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Project PATOV

Project PATOV. P rocess A nalytical T echnology Unit for O nline V erification of the CIP Process in the Pharmaceutical Industry Stefan Pohn Markus Brandstetter Tanja Siegmann- Hegerfeld Michael Harasek mharasek@mail.zserv.tuwien.ac.at www.patov.eu. Project PATOV.

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Project PATOV

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  1. Project PATOV Process Analytical Technology Unit for Online Verification of the CIP Process in the Pharmaceutical Industry Stefan Pohn Markus Brandstetter Tanja Siegmann-Hegerfeld Michael Harasek mharasek@mail.zserv.tuwien.ac.at www.patov.eu

  2. Project PATOV • Actual technologies for measuring the contamination in Cleaning in Place (CIP) waste water are slow (~10min) • The aimisto find a newtechnologyfor online verification • Implementing an IR technology (~1 measurementevery 1-30s) • Realisedwithintheproject PATOV, financedbythe 7th Framework Program ofthe EU

  3. Project PATOV • Experimental CIP plant installed at Vienna University of Technology • Plant is able to reproduce a CIP procedure • Resultsachievedwiththe IR equipmentarevalidatedwith offline TOC (total organiccarbon) measurements • PATOV isplacedclosetothe CIP plant tomeasurethecontamination in the CIP processwater

  4. Project PATOV • Schematic of experimental CIP plantwith PATOV unit

  5. Project PATOV PATOV unit CIP waterstorage tank Vesselthat has to becleaned Pumps forcyclingthewater Connection PATOV-CIP system

  6. Project PATOV Actual Status of the Project • At the moment it is possible to make a measurement every second • Down to a concentration of 20ppm • Retention time from the CIP plant to the PATOV unit was brought down to 15s • Only one contaminant can be measured at the moment, the calibration for other contaminants, like proteins is planned

  7. Project PATOV Project Partners Visitus @ www.patov.eu

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