1 / 30

Understanding Xenobiotics and Environmental Toxins: Impact on Health

Learn about xenobiotics, exogenous chemicals found in air, water, soil, and food that enter the body through different routes. Discover how xenobiotics undergo detoxification or activation processes in two phases, impacting cellular health. Explore environmental pollution types like air and indoor pollution, their effects on respiratory health, and the importance of detoxification enzymes like Cytochrome P-450.

duyen
Télécharger la présentation

Understanding Xenobiotics and Environmental Toxins: Impact on Health

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Environmental and Nutritonal diseases • Toxicology • Xenobiotics These r exogenous chemicals present in air,water,soil,and food • Enter the body thrskin,inhalation,injestion, • Some xenobiotcs • Form inactive water soulble products called detoxification

  2. Or activated to form toxic metabolites • 2 phases • Phase 1chemicals undergo hydrolisis,oroxidation,or reduction become water soluble • Phase 2 glucuronidnation,sulfation,methylation

  3. The most important catalyst in phase 1 is • Cytochrome P 450 enzyme they detoxify or activate the xenophyte to cause cellular injury.n by both reactive oxygen species which cause cellular damage

  4. Envirnomental pollution • Air pollution • Ozone – Injury to resp n alveoli results in URTI and inflammation esp in asthmatics, emphysema • The reaction air way hyperactivity and NEUTROPHILIA

  5. Sulfur dioxide • Particulate matter soot espog 10micromt diameter is harmful • CO carboxyhemoglobin,cherry red clolr spots with acute poisoning • Indoor pollution • Tobacco smoke • Wood smoke, bioaerosoles, formaldehyde

More Related