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Testing the antidepressant efficacy of P2X7 antagonist in M. bovis , BCG challenged mice.

Testing the antidepressant efficacy of P2X7 antagonist in M. bovis , BCG challenged mice. Jason O’COnnor. Sucrose Preference Test. *. Significant two way interaction, only a significant BCG effect observed in control group. No other groups are significantly different from each other.

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Testing the antidepressant efficacy of P2X7 antagonist in M. bovis , BCG challenged mice.

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  1. Testing the antidepressant efficacy of P2X7 antagonist in M. bovis, BCG challenged mice. Jason O’COnnor

  2. Sucrose Preference Test * Significant two way interaction, only a significant BCG effect observed in control group. No other groups are significantly different from each other.

  3. Open Field Test Locomotor activity Anxiety-like behavior No difference in locomotor activity between groups. A significant main effect of BCG in duration of time spent in central area (anxiety-like phenotype)

  4. Social Interaction Test No significant two way interaction (p=0.1), only a significant BCG effect observed in control group. *

  5. Y-maze Spontaneous Alternation Significant two way interaction, only a significant BCG effect observed in control group. No other groups are significantly different from each other. *

  6. Tissues collected • Plasma • At the end of behavioral study • In a small parallel group of mice at 8d post BCG • Brains (cortical hemispheres and cerebellum) • At the end of behavioral study • In a small parallel group of mice at 8d post BCG • Lung • At the end of behavioral study • In a small parallel group of mice at 8d post BCG

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