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Preliminary data on the Naples ’ cohort

Preliminary data on the Naples ’ cohort. 31.12.2012. Naples Prevent Cohort. 306 newborns from at risk families, with a confirmed case of CD among parents or sibs, were eligible for the study (01/01/2007 to 31/12/2011 ): 256 Prevent + 50 Neocel

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Preliminary data on the Naples ’ cohort

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  1. Preliminary data on the Naples’ cohort 31.12.2012

  2. NaplesPreventCohort 306 newborns from at risk families, with a confirmed case of CD among parents or sibs, were eligible for the study (01/01/2007 to 31/12/2011 ): 256 Prevent + 50 Neocel • 207 newborns entered the study on the basis of DQ2/DQ8 positivity: 171 Prevent + 36 Neocel • 99 newborns were DQ2 and DQ8 negative and were followed up at 3-5 years as controls: 78 Prevent + 21 Neocel

  3. 100 mg GLUTEN WORSE THAN PLACEBO 13 new cases were registered at 36 months of follow up (CI 6%), 8% by 48 months and does not increase by 60 months (5 years).

  4. Cumulative incidence of CDby gender

  5. Cumulative incidence of CDby HLA-type (n=910) P<0.0001 14% 14% 72%

  6. Result-6:DISCRIMINANT ANALYSIS Sex, HLA risk, breastfeeding, proband: VariablesEntered/Removed(a,b,c,d) StepEnteredWilks' Lambda Statistic df1 df2 df3 Statistic df1 df2 Sig. 1 RISK ,983 1 1 185,000 3,156 1 185,000 ,077 sex ,971 2 1 185,000 2,789 2 184,000 ,064 Only 65.2% oforiginalgroupcases are correctlyclassified.

  7. % events in 16 CDcases vs 188 controls

  8. EVENTS • Celiac Cases show an excess of adverse events till 24 months: specifically they suffered from about double Upper Respiratory and Lower Respiratory Infections, more Fever lasting > 3 days , more Vomiting . • Up to 12 months they also showed more frequently Constipation. • There was no difference in the frequency of acute gastroenteritis or ‘colicky’ abdominal pain. • It is interesting to observe that such differences were not any more present after the 24 months, where most of the cases were already diagnosed and put on a gluten free diet.

  9. Conclusions • CI at 4 yearsisabout12 % • 100 MG GLUTEN AT 4 MONTHS DO NOT PREVENT , BUT MY BE WORSE IN GIRLS • HLA riskis a major riskfor the predictionofvillousatrophy, asfatherasproband. • Relevantevents in the first 2 yearsof life CDcorrelatedseem URTI and LRTI, more thangastroenteritis.

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