1 / 44

Master Thesis Colloquium 18-2-2011

A preliminary study to improve the mammographic breast cancer screening with the implementation of a local pressure sensing system. Master Thesis Colloquium 18-2-2011. Introduction. Breast cancer. Most common cancer in women 1 out 8 women get any form of breast cancer

edita
Télécharger la présentation

Master Thesis Colloquium 18-2-2011

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. A preliminary study to improve the mammographic breast cancer screening with the implementation of a local pressure sensing system Master Thesis Colloquium 18-2-2011

  2. Introduction • Breast cancer • Most common cancer in women • 1 out 8 women get any form of breast cancer • 15% of all cancer deaths caused by breast cancer • Fairly treatable disease when detected early

  3. Introduction • Mammography Breast cancer detection Screening (mammography) Diagnosing

  4. Introduction • Mammography

  5. Introduction • Mammography X-ray CC X-ray MLO

  6. Introduction • Mammography

  7. Objective • Title A preliminary study to improve mammographic breast cancer screeningwith the implementation of a local pressure sensing system. A preliminary study to improve mammographic breast cancer screening with the implementation of a local pressure sensing system. • Same protocol as used in standard mammography • No additional time and operation • Same compression A preliminary study to improve mammographic breast cancer screening with the implementation of a local pressure sensing system.

  8. Objective • Pre-menopausal breast Fat Mammary gland Cooper’s ligaments Elasticity fat converges to elasticity glandular tissue in large deformations [1] [1] Azaret al.

  9. Objective • Post-menopausal breast Fat Healthy breast tissue Mammary gland Cooper’s ligaments Glandular tissue atrophies

  10. Objective • Cancerous breast • Tumor • Spherical shape • Higher stiffness (8-20 times)

  11. Objective • Problem description Simplification of the problem: Geometry Physiology 30 mm Breast containing a tumor Cylinder containing an inclusion

  12. Contents • Contents

  13. Contents • Contents

  14. Contents • Contents

  15. Theoretical study • Finite Element Analysis Th R P

  16. Theoretical study • Finite Element Analysis Input parameters: Relative elasticity (Ehealtytissue : Etumor ) Depth (P) Radius (R) Relative elasticity (E1/E2) Depth (P)

  17. Theoretical study • Finite Element Analysis Input parameters: Relative elasticity (Ehealtytissue : Etumor ) Depth (P) Radius (R) Relative elasticity (E1/E2) Depth (P)

  18. Theoretical study • Results Peak value Relative stress Depression Footprint (L) 0 -1 1

  19. Theoretical study • Peak value Peak Peak Relative elasticity (E1/E2) Relative depth (P/R) Peak value E2 E1 P 2R

  20. Theoretical study • Footprint Footprint (D/L) Footprint (D/L) Relative depth (P/R) Relative elasticity (E1/E2) E2 E1 2R P Footprint (L)

  21. Contents • Contents

  22. Experimental study • Setup Tensile tester Line-array pressure sensors Silicone tissue phantom

  23. Experimental study • Setup Tensile tester Line-array pressure sensors Silicone tissue phantom

  24. Experimental study • Setup Tensile tester Line-array pressure sensors Silicone tissue phantom

  25. Experimental study • Setup

  26. Experimental study • Problems during experimental study Lubrication layer to overcome shear stresses at the surface

  27. Experimental study • Results Relative stress X (mm)

  28. Experimental study • Results Relative stress X (mm)

  29. Experimental study • Results Relative stress X (mm)

  30. Experimental study • results 12mm inclusion Relative stress X (mm)

  31. Contents • Contents

  32. Conclusions • Conclusions Theoretical study • A peak is found in vertical stress distribution around an inclusion • Relative depth (P/R)  Does influence the stress distribution • Relative elasticity (E1 / E2 )  Does not influence the stress distribution Experimental study • Inclusions smaller than 10 mm are not detected in the experimental study • Implementation in standard mammography is possible • Radio lucent pressure sensors • Filtering of shear stresses along surface Objective: Feasibility of implementing local pressure sensors in standard mammographic devices Promising feature to detect tumors

  33. Conclusions • Where will this lead to..

  34. Contents • Contents

  35. Recommendations • Theoretical study • Better geometry of the breast • Extending material properties: • Absolute elastic behavior • Viscoelastic behavior • Analytical definition of stress behavior around inclusion • validate finite element analysis.

  36. Recommendations • Experimental study • Improving pressure sensing system • Radio-lucent pressure sensing system • 2-dimensional instead of 1-dimensional • Higher accuracy of the sensors • Higher resolutions of the sensors

  37. THANK YOU FOR YOUR ATTENTION!

  38. Experimental Study • results

  39. Single sensor setup Single sensor circuit

  40. Objective • Analytical problem

More Related