Chapter 1, 2, 3, and 5 Review

1. Chapter 1, 2, 3, and 5 Review

2. CHAPTER 1

3. OVERVIEW: Anatomy • brain is the body’s control center

4. OVERVIEW: Neurons CELL BODY: contains nucleus and cytoplasm AXONS: extensions of the cell body which end in nerve terminals DENDRITES: extensions of the cell body which receive messages from other neurons SYNAPSES: junction between two nerve cells MYELIN SHEATH: layer of glia which covers the axons GLIA: specialized cells which perform many jobs

5. OVERVIEW: Neurons

6. continued... ION CHANNELS: selectively-permeable tunnels which allow movement of ions into and out of neurons ACTION POTENTIAL: change in the charge of a neuron when the electrical changes reach the end of an axon, they trigger …

7. History of neurotransmitters • 1921: Austrian scientist Otto Loewi discovers the first neurotransmitter found a chemical which he called “Vagusstoff”

8. Acetylcholine (ACh) • found in autonomic, central, and peripheral nervous systems

9. Amino acids • building blocks of proteins; some also serve as neurotransmitters ONES TO KNOW: glutamate glycine aspartate gamma-aminobutyric acid (GABA)

10. Catecholamines “FIGHT OR FLIGHT” RESPONSE! epinephrine dopamine (DA) norepinephrine (NE)

11. Histamine • grouped as “small molecular neurotransmitter substance” along with serotonin, adrenaline, and dopamine • produced during allergic reaction • helps keep body awake

12. Serotonin (5-HT) Peptides Trophic Factors

13. Hormones • chemical signals of the ______ system • six classes of steroid hormones: androgens, estrogens, progestins, glucocorticoids, mineralocorticoids, and vitamin D

14. Lipid messengers • prostaglandins • How does aspirin work? • endocannabinoids

15. Unusual neurotransmitters • gases • NO • causes changes in blood vessels • CO • relaxes muscles around blood vessels

16. Second messengers http://highered.mcgraw-hill.com/olcweb/cgi/pluginpop.cgi?it=swf::535::535::/sites/dl/free/0072437316/120069/bio07.swf::Second%20Messengers%20-%20The%20cAMP%20and%20Ca++%20Pathways 3 major classes: • cyclic nucleotides • inositol trisphosphate & diacylglycerol • calcium ions

17. Movement of neurotransmitters released at nerve terminals diffuse across the synapse bind to receptors of target cell “key & lock mechanism”

18. Ionotropic vs. Metabotropic receptors Can you identify which one is which? http://sites.sinauer.com/neuroscience5e/animations05.03.html

19. Inactivation of neurotransmitters 1) 2) 4) 3)

20. CHAPTER 2

21. CHAPTER 3

22. Background • Studies about visual transduction, or how light is converted into electrical signals, comes from studies of Drosophila (fruit flies) and mice • Visual processing (how we interpret the light signals) has been mostly studied in monkeys and cats.

23. How sight works • As in a camera or a mirror, the image on the retina is reversed: Objects to the right of center project images to the left part of the retina and vice versa; objects above the center project to the lower part and vice versa. • Muscles behind the iris regulate the size of the pupil (different size means farther/nearer objects shifted to focus)

24. sight • Cornea focuses light • Lens adjusts the light • Both combine to produce a clear image of the visual world on a sheet of photoreceptors called the retina • Photoreceptors gather visual information by absorbing light and sending electrical signals to other retinal neurons for initial processing and integration • signals are then sent via the optic nerve to other parts of brainthat process the image

25. More on photoreceptors • Photoreceptors, about 125 million in each human eye, are neurons specialized to turn light into electrical signals. • 2major types of photoreceptors are rods and cones. • Rods are extremely sensitive to light and allow us to see in dim light, but they do not convey color. Rods constitute 95 percent of all photoreceptors in humans. • Most of our vision, however, comes from cones that work under most light conditions and are responsible for acute detail and color vision • three types of cones (red, green and blue), each sensitive to a different range of colors

26. Right and left perception • Objects on left side of vision register to right side of cortex; the left half of the scene you are watching registers in the cerebrum’s right hemisphere. • A similar arrangement applies to movement and touch • Each half of the cerebrum is responsible for processing information received from the opposite half of the body.

27. layers • The retina contains three organized layers of neurons. • The rod and cone photoreceptors in the first layer send signals to the middle layer (interneurons), which then relays signals to the third layer, consisting of multiple different types of ganglion cells, specialized neurons near the inner surface of the retina. • Can notice fine details in middle of sight because only receives signal from one photoreceptor, at the sides, the ganglion receive signals from many photoreceptors

28. The brain • Info from retina (the three layers) is relayed through the lateral geniculate nucleus of the thalamus to the primary visual cortex — a thin sheet of tissue (less than one-tenth of an inch thick), a bit larger than a half-dollar, which is located in the occipital lobe in the back of the brain. • The primary visual cortex is densely packed with cells in many layers, just as the retina is. In its middle layer, which receives messages from the lateral geniculate nucleus, scientists have found responses similar to those seen in the retina and in lateral geniculate cells. • Cells above and below this layer respond differently. They prefer stimuli in the shape of bars or edges and those at a particular angle (orientation). • movement, depth, perspective, the relative size of objects, the relative movement of objects, shading, and gradations in texture all depend primarily on contrasts in light intensity rather than on color.

29. Where is all this happening?

30. Research Leads to More effective Treatment • Extensive genetic studies and use of model organisms have allowed us to identify defects in inherited eye diseases, making it possible to design gene or stem cell-based therapy and discover new drugs for treatment. • Loss of function or death of photoreceptors appears to be a major cause of blindness in many diseases that are currently incurable. • Recently, gene therapy for a small group of patients with severe blindness allowed them to see. • Work also is in progress to bypass lost photoreceptors and send electrical signals directly to the brain via ganglion cells.

31. review • Take a moment to review the layers of the primary visual cortex • Give an example of how research leads to treatment

32. hearing • Our hearing system does not blend the frequencies of different sounds, as the visual system does when different wavelengths of light (different intensity)are mixed to produce color. • Instead, it separatescomplex sounds into their component tones or frequencies so that we can follow different voices or instruments as we listen to conversations or to music. • Hair cells (detect vibrations), cohclea, malleus (the hammer) and other parts of the ear all detect sounds • The auditory nerve then carries the signals to the brainstem. Each nerve fiber carries information about a different frequency to the brain. • Auditory information is analyzed by multiple brain centers as it flows to the superior temporal gyrus, or auditory cortex, the partofthe brain involved in perceiving sound.

33. Picture of the ear

34. Taste and Smell • Tastants, chemicals in foods, are detected by taste buds, special structures embedded within small protuberances on the tongue called papillae. Other taste buds are found in the back of the mouth and on the palate. • Every person has between 5,000 and 10,000 taste buds. Each taste bud consists of 50 to 100 specialized sensory cells, which are stimulated by tastants such as sugars, salts, or acids. • When the sensory cells are stimulated, they cause signals to be transferred to the ends of nerve fibers, which send impulses along cranial nerves to taste regions in the brainstem. • From here, signals go to thalamus, and on to a specific area of the cerebral cortex, which makes us conscious of the perception of taste.

35. Taste and smell • Airborne odor molecules, called odorants, are detected by specialized sensory neurons located in a small patch of mucus membrane lining the roof of the nose. Axons of these sensory cells pass through perforations in the overlying bone and enter two elongated olfactory bulbs lying against the underside of the frontal lobe of the brain. • Odorants act on receptors to varying degrees (different reactions for different ones) • Olfactory information passes to adjacent parts of the orbital cortex, where the combination of odor and taste information helps create the perception of flavor.

36. Pain (a brief overview) • Different parts of the body vary in their sensitivity to tactile and painful stimuli. These varying responses are based largely on the number and distribution of receptors. • For example, the cornea is several hundred times more sensitive to painful stimuli than are the soles of the feet. • Pain messages can be suppressed by systems of neurons that originate within the gray matter in the brainstem. These descending systems suppress the transmission of pain signals from the dorsal horn of the spinal cord to higher brain centers. • Some of these descending systems use naturally occurring chemicals, the endogenous opioids, or endorphins, which are functionally similar to morphine. • Recent findings indicating that endorphins act at multiple opioid receptors in the brain and spinal cord have had important implications for pain therapy.

37. CHAPTER 4

38. What does the medial temporal region deal with? Learning, Memory, and Language H.M. Study — what was it and what impact did it have on neuroscience?

39. Learning, Memory, and Language DECLARATIVE MEMORY • working memory • semantic memory • episodic memories NONDECLARATIVE MEMORY • procedural memory

40. Learning, Memory, and Language STORING MEMORY • involves … • LTP • NOTE: NO SINGLE BRAIN CENTER STORES MEMORY LANGUAGE • APHASIAS • nonfluent aphasias • fluent aphasia • word deafness } IMPACT?

41. CHAPTER 5

42. Muscles • Skeletal Muscle • Muscles that connect to the skeleton • Spans over joints and controls them • Closes Joint: Flexor (Bicep) • Opens Joint: Extensor (Tricep) • Agonist: Moves a joint in an intended direction • Antagonist: Opposes the agonist

43. Muscles • Each muscle contains thousands of muscle fibers • Each muscle fiber is controlled by an Alpha Motor Neuron • In the brain/spinal cord • Each controls many fibers – fibers + alpha motor neuron = Motor unit • Critical link between brain and muscle • If motor units die (Amyotrophic Lateral Sclerosis)– muscle cannot be moved

44. Involuntary Movements • Reflexes – automatic responses to specific stimuli • Eg. Doctors hitting knee • Activation of small sensory receptors in skin, joints, muscles (muscle spindles) • Spindles – Send information to spinal cord and brain (length and speed of muscle shortening) • Used for voluntary and involuntary movements

45. Involuntary Movements • Stretch sends impulse to the spinal cord through muscle spindle sensory fibers (like train-tracks) • Send response back, activating motor neurons • Also cause inactivation of antagonists

46. Involuntary Movements • Also controls feedback as movements occur • Sensitivity of muscles monitored through gamma motor neurons • Golgi tendon organs – detect force applied by contraction – allow brain to sense force exerted • Coordinated/organized differently based on situation – holding teacup/throwing ball

47. Involuntary Movements • Flexion withdrawal • Stimulus in one part of body activates reflex in other part • Eg- stepping on broken glass • Standing up = crossed extension reflex

48. Complex Movements • Spinal neurons control complex movements (walking) • Controlling spinal mechanisms by brain=most complex functions (dance) • Motor cortex – controls spinal cord (through alpha motor neurons) • Some neurons control many muscles, some do few (in hands – finely tuned)

49. Complex Movements • Movement from basal ganglia, thalamus, cerebellum, many neurons in midbrain/brainstem as well • Regions that send axons to spinal cord • Dopamine helps control movement when in basal ganglia • Parkinsons don’t get dopamine from midbrain – rigid, tremorous, unable to move

50. Complex Movements • Movement from basal ganglia, thalamus, cerebellum, many neurons in midbrain/brainstem as well • Regions that send axons to spinal cord • Dopamine helps control movement when in basal ganglia • Parkinson’s don’t get dopamine from midbrain – rigid, tremulous, unable to move