1 / 39

Blood Film

Blood Physiology Lecture -4 White Blood Cells –cont Professor A.M.A Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of Medicine & The Blood Bank, King Khalid University Hospital King Saud University Riyadh. Blood Film.

ehren
Télécharger la présentation

Blood Film

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Blood PhysiologyLecture -4White Blood Cells –contProfessor A.M.A Abdel GaderMD, PhD, FRCP (Lond., Edin), FRSH (London)Professor of Physiology, College of Medicine &The Blood Bank, King Khalid University HospitalKing Saud UniversityRiyadh

  2. BloodFilm

  3. White Blood Cells–cont- Agranulocytes – Objectives of the lecture: At the end of this lecture the student should be able to: • Describe monocyte formation and function • Describe the reticuloendothelial system components and function • Describe lymphocyte formation • Describe the functions of the diffrerent types of lymphocytes • Recognize leucocytosis, leucopenia and leukaemia

  4. White Blood Cells –contAgranulocytes Contents: • Monocyte formation, maturation and function • Reticulendothelial system components and function • Lymphocyte formation and function • Leucocytosis, leucopenia and leukaemia

  5. Leucocytes (WBCs) – cont. • Types of WBC • Granular WBC: • Neutrophils • Eosinophils • Basophils 2. Agranular WBC • Monocytes 5.3% • 15-20um, kidney shape nucleus • Lymphocyte 30%

  6. Leucocytes (WBCs) – cont. • Types of WBC • Granular WBC: • Neutrophils • Eosinophils • Basophils 2. Agranular WBC • Monocytes • Lymphocyte 30%

  7. Leucocytes (WBCs) – cont. • Types of WBC • Granular WBC: • Neutrophils • Eosinophils • Basophils 2. Agranular WBC • Monocytes • Lymphocyte

  8. Leucocytes (WBCs) – cont. • Types of WBC • Granular WBC: • Neutrophils • Eosinophils • Basophils 2. Agranular WBC • Monocytes • Lymphocyte

  9. Leucocytes (WBCs) – cont. • Types of WBC • Granular WBC: • Neutrophils • Eosinophils • Basophils 2. Agranular WBC • Monocytes • Lymphocyte

  10. Leucocytes (WBCs) – cont. • Types of WBC • Granular WBC: • Neutrophils • Eosinophils • Basophils 2. Agranular WBC • Monocytes • Lymphocyte

  11. Leucocytes (WBCs) – cont. • Types of WBC • Granular WBC: • Neutrophils • Eosinophils • Basophils 2. Agranular WBC • Monocytes • Lymphocyte

  12. Defensive Functions of the Monocytes • Directly: • phygocytosis of bacteria, dead cells etc • Indirectly: • Cooperates with lymphocytes by: • Recognizing the foreign body • Ingesting the foreign body • Processing the foreign body • Presenting it to lymphocytes

  13. Leucocytes (WBCs) – cont. • Types of WBC • Granular WBC: • Neutrophils • Eosinophils • Basophils 2. Agranular WBC • Monocytes • Lymphocyte

  14. Leucocytes (WBCs) – cont. • Types of WBC • Granular WBC: • Neutrophils • Eosinophils • Basophils 2. Agranular WBC • Monocytes • Lymphocyte

  15. Hemopoiesis (17.9)

  16. Lymphocytes– cont. Lymphopoiesis Stem cell (thymus, lymphoid tissue & bone marrow) lymphoblast intermediate pyronophilic blast cells lymphocytes

  17. Immunity -- Types Acquired immunity: • Basic types of acquired immunity: Humoral immunity (B-cell immunity) B-LYMPHOCYTES Antibodies Cell-mediated immunity (T-cell immunity) Activated T-LYMPHOCYTES Initiated by antigens

  18. The bases of Acquired Immunity are Lymphocytes

  19. Immune cells Two types: • B-Lymphocytes (Thymus independent, B-lymphocytes) Produce antibodies (Humoral Immunity) 2. T- lymphocytes (Thymus dependent, T-lymphocytes) Cellular mechanisms (Cellular Immunity)

  20. Functions of Leucocytes- WBCSummary • Defence of the body against infections and foreign invadors Neutrophils & monocytes (Blood macrophages)-Phgaocytosist/ + Immunity Macrophage (RES) system … Phagocytosis + Immunity Lymphcytes ….. IMMUNITY

  21. White Blood Cells –contAgranulocytes Contents: • Monocyte formation, maturation and function • Reticulendothelial system components and function • Lymphocyte formation and function • Leucocytosis, leucopenia and leukaemia

  22. Leucocytosis(Increased WBC Count) Causes: • Physiological • Diurnal: morning  evening • After physical exercise • Stress or Adrenaline injection • Disease (pathological) • Bacterial infections (tonsillitis, appendicitis • Worms infestations

  23. Leucopenia(Decreased WBC Count) Causes: • Malnutrition • Typhoid fever • Depressed bone marrow • Deficiency of Vit B12 or folic acid

  24. The Macrophage system Reticulo-endothelial System(RES)

  25. Reticuloendothelial System-RES • RES is widespread in the body Cells of the RES: • Monocytes (blood macrophages) • Mobile and fixed tissue Macrophages • Endothelial cells in bone marrow, lymph nodes and spleen • Reticular cells of lymph nodes spleen & bone marrow.

  26. Reticuloendothelial System-RESCells of the RES - Distribution: • Tissue Macrophages in skin SC tissues • Tisssue Macrophages of lymph nodes • Tissue macrophages in lungs • Macrphages (kupffer cells) in the liver • Macrphages in the spleen and bone marrow

  27. Functions of Reticuloendothelial system • Phagocytosis: Bacterial, dead cells, foreign particles • Breakdownof Hb • Immune function: processing antigen and antibodies production (indirect) • Storage of iron Dr Sitelbanat

  28. White Blood Cells –cont- Agranulocytes – Objectives of the lecture: At the end of of this lecture the student should be able to: • Describe monocyte formation and function • Describe the reticuloendothelial system components and function • Describe lymphocyte formation • Describe the functions of the diffrerent types of lymphocytes • Recognize leucocytosis, leucopenia and leukaemia

  29. THANK YOU لكم جزيل الشكر

  30. THANK YOU لكم جزيل الشكر

More Related