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Major Histocompatibility Complex & Transplantation: Understanding HLA and Graft Acceptance

Learn about the role of histocompatibility in transplantation, including HLA system, MHC molecules, tissue typing, clinical phase of rejection, and prevention of graft rejection.

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Major Histocompatibility Complex & Transplantation: Understanding HLA and Graft Acceptance

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  1. Major Histocompatibility Complex &Transplantation Prepared by; 伟大默涵 苏丽 克劳德 阿密特 吉尔伯特 Shandong University School Of Medicine 25.04.2017

  2. Simple AND Easy Questions • What is Histocompatibility means Histocompatible; Pertaining to donor and recipient who share a sufficient number of (Histocompatibility Antigens). So that a graft is accepted and remains functional. Transplantation; process of transplanting or process of removing from one place and planting or resettling in another, grafting.

  3. INTRODUCTION • Transplantation • What is Transplantation? • Roles of Histocompatibility in Transplantation. • Transplantation Antigens. • HLA system. • Identifying MHC Polymorphisms. • tissue typing • Clinical phase of rejection. • Graft acceptance • Prevention of graft rejection. • MHC • Several Important concepts. • What is HLA? • MHC and its 3 classes, briefly. • MHC molecules with its classes. • Biological function of MHC. • MHC with 3 different classes regions. • MHC linked disease.

  4. According to United Network For Organ Sharing … • There are; • 117.991people need a lifesaving organ transplant. • ------------------------------------------------------ • 8,365, transplants performed this year, • Total Transplants January - March 2017 as of 04/21/2017. • 3,948donors.Total Donors January - March 2017 as of 04/21/2017. https://www.unos.org/data/

  5. Several Important concepts

  6. “MHC”Major Histocompatibility Complex

  7. “MHS” Major Histocompatibility Antigen System

  8. “Mhs” Minor Histocompatibility Antigen It is a group of complex histocompatibility antigens which cause slow and weak immunoreaction to the graft

  9. “HLA” Human Leucocyte Antigen

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  11. Class I and II MHC Molecules

  12. Transplantation. TRANSPLANTATION: immunology the term transplantation is used to refer the procedure involved in the replacement of a nonfunctional or damaged organ or tissue with a good, and functional organ or tissue to safe guard the life of an individual. heterotopic transplantation. Blood transfusion; is a form of transplantation in whichwhole blood or blood cells from one or more individualsare transferred intravenously into the circulation ofanother individual.

  13. Roles of Histocompatibility in Transplantation • the recipient's immune system will react naturally as if the tissue is a dangerous foreign antigen and cause an immune response to destroy the tissue. • This response will continue unless the MHC proteins expressed by the donor's tissue are the same, or at least very similar to the MHC proteins expressed by the recipient's, for which it has LEARNED not to react against. • This is why most transplants will require post-operative immunosuppressant therapy to lessen the immune response to the transplant and prevent tissue rejection - unless the transplanted tissue enjoys immune privilege, such as with corneal transplants.

  14. In Conclusion we talked about; MHC • Several Important concepts. • What is HLA? • MHC and its 3 classes, briefly. • MHC molecules with its classes. • Biological function of MHC. • MHC with 3 different classes regions. • MHC linked disease. • What is Transplantation? • Roles of Histocompatibility in Transplantation. • Transplantation Antigens. • HLA system. • Identifying MHC Polymorphisms. • tissue typing • Clinical phase of rejection. • Graft acceptance • Prevention of graft rejection. Transplantation

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