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Glycolysis, glycogenesis, and glycogenolysis

Glycolysis, glycogenesis, and glycogenolysis. Embden-Meyerhoff pathway (glycolysis) Blood glucose uptake Lactate metabolism Glycogenesis (glycogen formation) Glycogenolysis (glycogen breakdown) Regulation of glycogenolysis Glycogen use during exercise. Glycolysis. Brooks et al.

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Glycolysis, glycogenesis, and glycogenolysis

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  1. Glycolysis, glycogenesis, and glycogenolysis • Embden-Meyerhoff pathway (glycolysis) • Blood glucose uptake • Lactate metabolism • Glycogenesis (glycogen formation) • Glycogenolysis (glycogen breakdown) • Regulation of glycogenolysis • Glycogen use during exercise

  2. Glycolysis Brooks et al.

  3. Glycolysis Glucose uptake: role of insulin Thong et al., Physiology 20: 271, 2005

  4. Glycolysis Glucose uptake: role of insulin Brooks et al.

  5. Glycolysis Glucose uptake: role of exercise Rose and Richter, Physiology 20: 260, 2005

  6. Glycolysis Brooks et al.

  7. Glycolysis Functions of glycolysis: 1. Produce pyruvate/lactate (oxidative substrates) 2. Produce small amount of ATP (2-3 net) 3. Produce small amount of H+ (2 pairs) Murray et al., Harper’s Biochemistry, Lange, 1996

  8. Glycolysis Brooks et al.

  9. Glycolysis • Shuttles for moving reducing equivalents from the sarcoplasm into the mitochondria: • Malate-aspartate shuttle • Glycerol phosphate shuttle • (Intracellular) Lactate shuttle • mMCT – mitochondrial monocarboxylate transporter Juel and Halestrap, J Physiol 517: 633, 2000

  10. Glycolysis (Extracellular) lactate shuttle Brooks et al.

  11. Glycolysis Cori cycle Brooks et al.

  12. Glycolysis Blood lactate during exercise Seeherman et al., Resp Physiol 44: 11, 1981

  13. Glycolysis Blood lactate during exercise Brooks et al.

  14. Glycogenesis Brooks et al.

  15. Glycogenesis Glycogen synthase b (inactive) (epinephrine, Ca2+) ↕ Glycogen synthase a (active) (insulin,↑ G-6-P) Brooks et al.

  16. Glycogenesis Hultman et al., Muscle Metabolism during Exercise, Plenum, 1971

  17. Glycogenesis Åstrand, Textbook of Work Physiology, McGraw-Hill, 1970

  18. Glycogenesis Åstrand, Textbook of Work Physiology, McGraw-Hill, 1970

  19. Glycogenolysis Phosphorylase a regulation: 1. Pi** 2. Ca2+* 3. Catecholamine Phosphorylase b regulation: 1. 5'-AMP Brooks et al.

  20. Glycogenolysis Phosphorylase regulation: 1. Pi** 2. Ca2+* 3. Catecholamine Phosphorylase b regulation: 1. 5'-AMP Brooks et al.

  21. Glycogenolysis Glycogen use during exercise Brooks et al. 2nd ed., 1996

  22. Glycogenolysis Glycogen use during exercise Saltin and Gollnick, Exercise, Nutrition, and Energy Metabolism, Macmillan, 1988

  23. Glycogenolysis Glycogen use during exercise: histochemical myosin ATPase and periodic acid-Schiffs stains Wilmore and Costill, Physiology of Sport and Exercise, Human Kinetics, 2004

  24. Glycogenolysis Glycogen use during exercise Saltin and Gollnick, Exercise, Nutrition, and Energy Metabolism, Macmillan, 1988

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