Download
collaborative atorvastatin diabetes study cards n.
Skip this Video
Loading SlideShow in 5 Seconds..
Collaborative Atorvastatin Diabetes Study (CARDS) PowerPoint Presentation
Download Presentation
Collaborative Atorvastatin Diabetes Study (CARDS)

Collaborative Atorvastatin Diabetes Study (CARDS)

307 Vues Download Presentation
Télécharger la présentation

Collaborative Atorvastatin Diabetes Study (CARDS)

- - - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript

  1. Collaborative Atorvastatin Diabetes Study (CARDS) Atorvastatin 10 mg (n=1428) Patient Population • Type 2 diabetes mellitus • Men and women 40–75 years of age • Primary CHD and stroke prevention • LDL-C 160 mg/dL (4.14 mmol/L) • TG 600 mg/dL (6.78 mmol/L) • 1 additional RF • HTN (or on HTN treatment) • Retinopathy • Albuminuria • Current smoking 2838 patients 4-year follow-up Double-blind placebo (n=1410) • Primary endpoint: time to first major CV event (CHD death, nonfatal MI, unstable angina, resuscitated cardiac arrest, coronary revascularization, stroke • Secondary endpoints: total mortality, any CV endpoint, lipids, and lipoproteins Colhoun HM et al. Lancet 2004;364:685-696.

  2. CARDS: Patient Baseline Characteristics Colhoun HM et al. Lancet 2004;364:685-696. Reprinted with permission from Elsevier.

  3. CARDS: Patient Baseline Lipids *Median (interquartile range) Colhoun HM et al. Lancet 2004;364:685-696. Reprinted with permission from Elsevier.

  4. 0 0 1 1 2 2 3 3 4 4 4.5 4.5 CARDS: Lipid Levels by Treatment Total Cholesterol (mg/dL)Average difference 26%,54 mg/dL; P<0.0001 LDL Cholesterol (mg/dL)Average difference 40%,46 mg/dL; P<0.0001 Placebo Placebo Median LDL-C (mg/dL)* Atorvastatin Median TC (mg/dL)* Atorvastatin Years of Study Years of Study Colhoun HM et al. Lancet 2004;364:685-696. Reprinted with permission from Elsevier.

  5. CARDS: Effect of Atorvastatin on the Primary Endpoint: Major CV Events Including Stroke Relative Risk Reduction 37% (95% CI, 17–52)P = 0.001 Placebo127 events Cumulative Hazard, (%) Atorvastatin83 events 0 1 2 3 4 4.75 Years PlaceboAtorvastatin 14101428 13511392 13061361 10221074 651694 305328 Colhoun HM et al. Lancet 2004;364:685-696. Reprinted with permission from Elsevier.

  6. CARDS: Adverse and Serious Adverse Events Colhoun HM et al. Lancet 2004;364:685-696.

  7. Primary Prevention Trials of Lipid-Altering Therapy Including Patients with Diabetes * By history † Prospective trial in diabetic subjects; others are subgroup analyses ‡ Mean 30 mg/d § Type 1 or 2 diabetes Bays H et al. Future Cardiology 2005;1:39-59. | Colhoun HM et al. Lancet 2004;364:685-696. | Downs JR et al. JAMA 1998;279:1615-1622. | HPS Collaborative Group. Lancet 2003;361:2005-2016. | Sever PS et al. Lancet 2003;361:1149-1158. | Shepherd J et al. Lancet 2002;360:1623-1630. | Koskinen P et al. Diabetes Care 1992;15:820-825.

  8. Secondary Prevention Trials of Lipid-Altering Therapy Including Patients with Diabetes § Type 1 or 2 diabetes ¶ Prospective trial in diabetic subjects; others are subgroup analyses || Angiographic study *Includes stroke in 4D and VA-HIT †By history ‡By history or glucose 126 mg/dL Bays H et al. Future Cardiology 2005;1:39-59. | Pyörälä K et al. Diabetes Care 1997;20:614-620. | Haffner SM et al. Arch Intern Med 1999;159:2661-2667. | Goldberg RB et al. Circulation 1998;98:2513-2519. | Keech A et al. Diabetes Care 2003;26:2713-2721. | Serruys PWJC et al. JAMA 2002;287:3215-3222. | HPS Collaborative Group. Lancet 2003;361:2005-2016. | Wanner C. Presented at ASN annual meeting, 2004. | Rubins HB et al. Arch Intern Med 2002;162:2597-2604. | DAIS Investigators. Lancet 2001;357:905-910.