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Collaborative Model for Understanding Eating Behavior: Mechanisms of Overeating

This research spearheaded by Dr. Ellen Schur aims to develop a collaborative model to explore the complex mechanisms behind overeating. Focusing on genetic, behavioral, hormonal, and cognitive influences, the study employs cutting-edge fMRI techniques to identify neuroanatomical correlates of eating behaviors. By analyzing brain activity in response to images of high-calorie foods, the research seeks to unravel the intricate pathways connected to appetite and food intake. With multiple pilot studies and grant applications underway, this work represents a significant advancement in eating behavior research.

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Collaborative Model for Understanding Eating Behavior: Mechanisms of Overeating

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  1. A collaborative model for eating research Ellen Schur, MD, MS Division of General Internal Medicine, Harborview Section UW Department of Medicine

  2. Interdisciplinary research in eating behavior • K23 award to explore genetic, behavioral, hormonal, and cognitive mechanisms of overeating • Initial goal was to develop an fMRI tool for identifying neuroanatomical correlates of overeating

  3. Where to begin? • Google functional MRI study design • Read a few papers • Get some help from IBIC • Study design • Image acquisition • Data processing and analysis

  4. Brain areas crucial to energy homeostasis and perception of reward are selectively attuned to visual images of fattening foods Schur, et al, Intl J of Obesity, in press

  5. R Nucleus accumbens Midbrain 4 4 P < 0.001 P < 0.01 3 3 2 2 Mean activity (z-score) Mean activity (z-score) 1 1 0 0 -1 -1 0 60 120 180 240 300 360 0 60 120 180 240 300 360 Liquid meal Time elapsed since meal (min.) Time elapsed since meal (min.) Spontaneous meal Effect of a meal on activation in reward pathways • Extracted data from regions of interest for contrast of fattening > non-fattening food • Performed linear regression analysis

  6. Productive collaborative model • Developed tool useful for understanding the subjective experience of appetite that drives food intake • Methods paper published • 2 abstracts • 3 funded pilot studies • R03 and R01 applications submitted

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