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This presentation by Dr. Brian W. Tempest discusses critical strategic issues facing the pharmaceutical industry. It covers topics such as the impact of healthcare fraud, innovations, and cost management essential for survival in a changing market. Insights include the need for a shift from product-focus to patient-focus, challenges posed by patent expirations, and the evolving landscape of biosimilars. The presentation emphasizes the importance of adapting business models and managing costs effectively to sustain growth and competitiveness in global markets.
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Strategic Pharma Issues Dr. Brian W Tempest www.briantempest.com brian.tempest@clara.co.uk Mumbai, India January 2013
The Biggest Healthcare Fraud in History Source: Daily Mail 3 July 2012
Big Pharma Business Model Brokensource: Pharmatimes World News April 2012
USA Life Expectancy & Pharma CostsSource: US Health in International Perspective Jan 2013
The Strategic Changes by Big PharmaSource: FT December 5 2012, Franz Humer, Roche Chairman • Possible to cut 30-50% off development costs via CT efficiencies • Shift from product focus to patient focus using diagnostic tools • In Europe there isn’t one Government or politician interested in the health of the Industry • USA & Latin American countries open to rewarding innovation • Industry has to change fundamentally how it manages costs • Leaner headquarters & smaller central functions • Division of the industry into 2 parts • A Innovative businesses able to charge a premium price • B Large scale manufacturers who can compete on cost
The Teva Future – Standing StillSource: RBC Capital 12 December 2012
Teva Losing Control of Costs in the EUsource: Teva June 2012
Reference Pricing in Central Europe Source : Istanbul September 2012 • Pharma purchases reduced from 1.7% of GDP to 1.0% of GDP in Turkey • Russia, South Korea & Saudi Arabia health ministries now requesting Turkish prices • Everybody is referencing everybody else on Pharma prices in Europe • Bulgaria is currently referencing prices in 17 other countries
BiosimiIar Issues in EU/USA • Rituximab –100 pat Roche, >600 pat Generics • Interchangeability unlikely • Could be different INN name in USA and EU • Cabilly patents may delay US mAbs to 2018 • EU first mAb in 2013 from Hospira/Celltrion • Pharmacovigilance data needed • EPO side effects in Thailand widely quoted • 400 biosimilar manufacturers in China but none will reach EU/USA • Biobetters need a full dossier with health economic data
Sandoz Biosimilars – an 18 years ROIsource: Pharmacloud June 2012
NIBS (tyrosine kinase inhibitors)Will these small molecules replace mAbs? • Axitinib, Pfizer, cancer • Cediranib, AZ, cancer • Pazopanib, GSK, cancer • Regorafenib, Bayer, cancer • Semaxanib, Sugen, cancer • Sorafenib, Bayer(Nexavar),cancer • Sunitinib, Pfizer, cancer • Toceranib, Pfizer, cancer • Vandetanib, AZ, cancer • Tofactinib, Pfizer, RA
Hisun-Pfizer JV to have 1500 staff in 2013source: Fierce Pharma
Thank You brian.tempest@clara.co.uk www.briantempest.com