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Volumetric Studies

Volumetric Studies

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Volumetric Studies

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  1. Volumetric Studies

  2. Current Technology • Image Acquisition: • 1.5 Tesla GE scanner, 1 coronal SPGR, 1 axial Double Echo PD and T2w image. • Rigid Registration: • Mutual Information Alignment. • Brain Segmentation: • Expectation Minimization Segmentation in 4 tissue classes (White, Gray, CSF and Face). • Manual Segmentation of Regions Of Interests. • Statistical Analysis of the ROIs’ Volume.

  3. Brain Segmentation W. Wells

  4. Posterior Superior Temporal Gyrus (STG)Red = Left, Green= Right• Amygdala. Yellow = Left, Light Blue = Right• Hippocampus (Hipp.). Orange = Left, Dark Blue = Right • Parahippocampal Gyrus (PHG). Dark Pink = Left, Purple = Right L. Post. STG L. STG Hipp. PHG L. Amygdala. L. Ant. STG L. Post. STG L. Hipp. Hirayasu et al.

  5. Volumetric Studies Findings • Lateral Ventricles & CSF Enlargement. • Parietal Volume Reduction. • Temporal Lobe Volume Reductions • Amygdala-Hippocampal Complex, Parahippocampal Gyrus, & Superior Temporal Gyrus. • Prefrontal Volume Reduction. • Basal Ganglia (Caudate, Putamen, Globus Pallidus) increases and decreases.

  6. Volumetric Studies

  7. Shape: Global Measures J. Levitt and C.F. Westin

  8. Shape: Surface Based Analysis H.J. Park and J. Levitt

  9. Shape: Medial Representations J. Levitt and S. Bouix

  10. Technical Challenges • Image Quality and Acquisition Sequences. • Multi Channel Atlas Based Segmentation. • Multi Channel Image Registration. • Model Based Segmentation. • Shape Analysis. • Cortical Thickness.