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Pain Day – The Basics of Pain

Pain Day – The Basics of Pain. Randall Reed PhD Director Center for Sensory Biology Professor Department of Molecular Biology and Genetics Department of Neuroscience Department of Otolaryngology – HNS. Our Senses Share Many Common Properties. The IBBS Center for Sensory Biology

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Pain Day – The Basics of Pain

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  1. Pain Day – The Basics of Pain Randall Reed PhD Director Center for Sensory Biology Professor Department of Molecular Biology and Genetics Department of Neuroscience Department of Otolaryngology – HNS

  2. Our Senses Share Many Common Properties • The IBBS Center for Sensory Biology • Randall Reed - olfaction • Paul Fuchs - hearing • Michael Caterina - Pain/touch • Xinzhong Dong - Pain/touch • Craig Montell - vision/taste • Elisabeth Glowatzki - hearing • Jeremy Nathans - vision • King-Wai Yau - vision/olfaction • Angelika Doetzlhofer– hearing • Michael Deans - hearing

  3. Classic View of the Senses • The Five Senses - Provide Information • Vision • Smell • Taste • Hearing • Touch • Also Provide Protection

  4. The Spectrum of Sensations Pain from a Broad Perspective: Touch Itch Pain

  5. TRP Channels: MolecularGatekeepers for the Senses • TRP Channels Mediate: • Thermal Sensation / Pain • Taste Some aspects of: • Vision • Olfaction • Hearing

  6. The Senses: Targets of Environmental Assault • Sensory Systems lie at interface between our inner and outer world – Subject to Damage • Hearing Loss • Burn/Itch • Olfactory Loss • Light Induced Damage

  7. Key Opportunities/Practical Implications of Advances in Sensory Biology • Strategies to modulate (up or down) sensory perception (Pain/Auditory/Chemosensory) • Organization/Interaction of cells in tissues • Molecular and cellular genesis of specialized organelles • Understand processes of neuronal damage, repair and regeneration

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