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Smoking behavior associated genes

Smoking behavior associated genes Nicotinic Acetylcholine Receptor Families (CHRNA 1-10 & CHRNB 1-4), CYP2A6. rs686 in DRD1 (modulator of miRNA binding SNP from literature). Search for SNPs in 3’UTR that lie in the seed region of a miRNA PolymiRTS (320 SNPs) SNPInfo (109 SNPs)

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Smoking behavior associated genes

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  1. Smoking behavior associated genes Nicotinic Acetylcholine Receptor Families (CHRNA 1-10 & CHRNB 1-4), CYP2A6 rs686 in DRD1 (modulator of miRNA binding SNP from literature) • Search for SNPs in 3’UTR that lie in the seed region of a miRNA • PolymiRTS (320 SNPs) • SNPInfo (109 SNPs) • Patrocles (15 SNPs) • Included if predicted by at least 2 programs 12 SNPs • MAF > 5% 4 SNPs • Allele causes predicted change in thermodynamic interaction with 3’UTR (RNA Hybrid) 4 SNPs • Successful iPlex design for genotyping assay 3 SNPs • Genotyped in NCI-MD Case Control Study • Test cohort of 316 controls and 319 cases (European American) 3 SNPs Supplementary Figure 1: Flowchart detailing the selection process of SNPs. Rs686 in DRD1 was selected from the literature as being a miRNA-binding modulating SNP (Huang and Li, 2009 Biol Pschiatry, 65 9 702-705)

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