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Biosensors

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  1. Biosensors And how they are changing the world

  2. What are they? • A device that utilizes biological components to indicate the amount of a biomaterial

  3. Breakdown of Components. • Bioreceptor- detects analyte • Transducer- converts into readable form • Reader Device- displays information

  4. Biosensors in the Future What should a biosensor be? • Portable, easy to use, small • Easy to be manufactured in mass quantities • Low cost, affordable • Rapid results • Satisfy a large market

  5. Military Use • The military has funded research into biosensors • Mine sensing bacteria • Monitoring gasses on the battlefield • Detecting air-borne pathogens • To counter Bio-terrorism

  6. Agriculture • Detecting heavy metal ions, arsenic, ammonia in water sources • Brazilian researchers developing a pesticide detector

  7. Medical • Detecting bladder cancer and lyme disease • “Artificial Skin” using flexible biosensors that can aid in prosthetics • Glucose and Pregnancy Tests • Cholesterol Test was a failure

  8. Design Project Factor VIII producing E. coli

  9. What is Hemophilia A • Hemophilia affects the ability of the body to control blood clotting or coagulation • Hemophilia A is a genetic blood disorder that is caused by a Factor VIII deficiency • Hemophilia affects more than 17,000 people in the United States

  10. Current Treatment Options • Replacement therapy • Desmopressin • Antifibrinolytic Medicine

  11. Proposal Using E. coli, create a topical creme containing bacteria engineered to produce clotting factor VIII in order to help close external wounds for people with Hemophilia A

  12. ABC Transporter LSR Transport Cassette ATP ADP ATP Al-2 ADP LuxS LsrR Fibrin P P Factor VIII LsrR ADP ATP LuxS Porcine Coagulation Factor VIII Export Factor VIII molecules

  13. Advantages • Low Risk, using Pig Factor VIII • No chance of blood-transmitted disease • Works even with antibodies and inhibitors • Site Specific • No Injection required

  14. Improvements • Kill Switch • Does not solve internal bleeding • Separate design needed for Hemophilia B