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Drugs from the Sea: Bioactive Compounds from Marine and Freshwater Sources (CHM 5306: Special Topics in Biological Chemi

Drugs from the Sea: Bioactive Compounds from Marine and Freshwater Sources (CHM 5306: Special Topics in Biological Chemistry) Fall 2006. Dr. John P. Berry Tel.: 786 200 7914 E-mail: John.Berry@fiu.edu Office: CP 346 (W, F), Marine Sci. 354/332

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Drugs from the Sea: Bioactive Compounds from Marine and Freshwater Sources (CHM 5306: Special Topics in Biological Chemi

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  1. Drugs from the Sea: Bioactive Compounds from Marine and Freshwater Sources (CHM 5306: Special Topics in Biological Chemistry) Fall 2006 Dr. John P. Berry Tel.: 786 200 7914 E-mail: John.Berry@fiu.edu Office: CP 346 (W, F), Marine Sci. 354/332 Office Hours: W 3:15-5:15 (CP 346), or by appointment Credits: 3 Time/Day: Fridays, 8:00 am to 10:40 am Location: CP 107

  2. Overview • Oceans Are Diverse Habitats (e.g. coral reefs) • Ocean’s Diversity Mediated by Chemistry (i.e. “biologically active compounds”) • Diversity of Compounds from Marine Animals are Rich Source of Drugs

  3. Ocean Habitats are Diverse

  4. Freshwater Habitats • Lakes and Ponds • Rivers and Streams • Wetlands • Swamps, Bogs, Fens, etc. …also estuarine (i.e. “brackish”) habitats!

  5. Coral Reefs 23.5° N 23.5° S 255,330 sq. km. < 0.25% of the area of the ocean Coral Reefs ≤ 50 m deep (ocean is 3.8 km deep)

  6. Coral reefs are among the most complex habitats on Earth 25% of oceans fish 1 million species identified… …estimated 8 million to go!

  7. Sunlight Neritic Pelagic waves “Edge Effect” = two habitats meet Turbulent environment Light = photosynthesis Why are coral reefs so complex? Shore Deep Water = Colonization = High oxygen “Architecture”

  8. Communication Competition between species Defense against pathogens Defense against predators Many of the interactions in the coral reef are based on CHEMISTRY

  9. “Biologically Active Compounds” “Toxins” (Toxicology) “Drugs” (Pharmacology)

  10. Drugs from the Sea: Marine Animals Percent Compounds Tested by NCI with Significant Cytotoxicity

  11. Vast Majority of Drugs from Marine Invertebrates Microorganisms Green Algae Sponges Brown Algae Red Algae Tunicates Echinoderms Mollusca Cnidarians (e.g. Corals)

  12. Communication Competition between species Defense against pathogens Defense against predators Why so many biologically active compounds from invertebrates?

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