Collaborative Infrastructures for Health-Care Research

1. Collaborative Infrastructures for Health-Care Research The Indiana CTSI HUB William K. Barnett, Ph.D. Pervasive Technology Institute Indiana University AAAS Annual Meeting, Vancouver, CA. February 19, 2012

2. What is Translational Research?? • Not research for publication - research towards better health • ‘Bench to Bedside’ translational cycle • Partnerships with the Public, Community Groups, Industry. … Requires new forms of collaboration

3. Why are Life Science researchers collaborating more? • Intellectual capital is no longer in one place. • Collaborative and transdisciplinary research have greater potential. • Research facilities are distributed. • Online datasets are changing the research process.

4. How do Life Science researchers collaborate? “… researchers use a limited range of services, and resort to informal advice from colleagues, rather than institutional service teams; and although sharing and exchanging information of many kinds is central to the ethos of life science research, individual researchers wish to choose what to share, with whom, and when.” Robin Williams et al., Patterns of information use and exchange: case studies of researchers in the life sciences, British Library Research Information Network, 2009. http://www.rin.ac.uk/our-work/using-and-accessing-information-resources/patterns-information-use-and-exchange-case-studie

5. Types of Online Research Collaborations • Communities of independent scholars (nanoHUB) • Institutional collaborations (Indiana CTSI HUB) • Distributed research projects (NEESHub, cceHUB)

6. How are HUBs unique for health care research? • Not an application, but an application framework (HUBzero) that ties software together, allowing choice and rapid customization • Tools researchers want, integrated for trusted collaboration • Transparent access to computational resources ‘under the hood’ to directly support research and education

7. The Indiana Clinical and Translational Sciences Institute IU, Purdue, and Notre Dameresearchers engaged translational researchAdministrative support, funding, mentoring, education, core services, community engagement, collaboration tools, technology transfer support in one place.Research, community, and industry partners

8. A HUB of translational services HUB Online Grant System Indiana CTSI Service Cores HUB Profiles Research Resources Funding Research Networking Indiana CTSI Education Collaboration Education and Mentoring Indiana CTSI PDTs Community Partnerships Tech Transfer

9. Federated Logins…easier and more trusted access

10. Alfresco Share…user driven file sharing and collaboration

11. REDCap…easy clinical data management

12. Sample Collection Predictive Modeling Predictive Modeling Sample Collection Data & Tools Visual Analytics Clinical Patient Data Laboratory Analysis Clinical Patient Data Visual Analytics Laboratory Analysis cceHUB: Sophisticated multi-team workflows 5 team clinical research workflow from the Cancer Care Engineering HUB

13. i2iconnect.org…unique listings of potential industry partners

14. What HUBzero delivers to health-care research in Indiana and nationally • A flexible framework for applications • A trusted environment for research • Tools and workflows that meet investigator needs • Connections to other communities … Accelerating translation to health

15. Thank you.Questions?Bill Barnett, barnettw@iu.eduFor more information about the Pervasive Technology Institute, visit http://pti.iu.edu The project described was supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through Grants RR025759, RR025760 and RR025761. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.