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Patient characteristics (acute infection): longitudinal samples from 3 acutely infected patients

Patient characteristics (acute infection): longitudinal samples from 3 acutely infected patients. Very high viral loads ALT peaked then fell All 3 patients failed to clear HCV infection, and became chronically infected. Amplicons of HCV quasispecies analyzed. Regions studied.

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Patient characteristics (acute infection): longitudinal samples from 3 acutely infected patients

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  1. Patient characteristics (acute infection): longitudinal samples from 3 acutely infected patients • Very high viral loads • ALT peaked then fell • All 3 patients failed to clear HCV infection, and became chronically infected

  2. Amplicons of HCV quasispecies analyzed Regions studied 5’ UTR: untranslated, very low variability, used for subtyping Core: translated, well conserved E1/E2: envelope, includes HVR1 hypervariable region DNA barcoding

  3. HCV hypervariable regions

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