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Lassa Fever

Lassa Fever. by Carly Brown. Discovery. John Frame 1969 collaborated with Yale Arbovirus Research Unit. Type/Structure. Arenaviridae family spherical lipid membrane single-stranded RNA. Transportation. zoonotic host-multimammate rat genus Mastomys person to person.

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Lassa Fever

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  1. Lassa Fever • by Carly Brown

  2. Discovery • John Frame • 1969 • collaborated with Yale Arbovirus Research Unit

  3. Type/Structure • Arenaviridae family • spherical • lipid membrane • single-stranded RNA

  4. Transportation • zoonotic • host-multimammate rat • genus Mastomys • person to person

  5. Transportation(cont.) • urine & droppings • direct contact • airborne transmission

  6. Demographic Info. • at risk- those who live in areas with Mastomys rodents

  7. Statistics • 100,000 - 300,000 infections a year • 5,000 deaths • accounts for 10-16% admitted to hospitals

  8. Facts • 80% - no observable symptoms • 20% - severe multisystem disease • 1-3 weeks after contracted

  9. Symptoms • fever • malaise • throat lesions • pneumonia • abdominal pain • vomiting • diarrhea

  10. Symptoms(etc.) • retrosternal pain • back pain • cough • conjunctivitis • facial swelling • mucosal bleeding

  11. Neurological Problems • tremors • hearing loss • deafness occurs in 1/3 of cases

  12. Miscellaneous • 15-20% patients hospitalized die • 95% fetuses die • risky-women in 3rd trimester

  13. Ribavirin • antiviral drug • used with success

  14. Sources

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