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Long-Term Risks and Benefits of HRT: Insights from the WHI Study for Women Aged 50-79

This report analyzes the selected risks and benefits associated with combined estrogen and progestogen hormone replacement therapy (HRT) and estrogen-only HRT based on findings from the Women's Health Initiative (WHI) study over 5 to 7 years. The study encompasses 10,000 women aged 50-79, examining outcomes such as breast cancer, cardiovascular disease, strokes, and fractures. Key findings indicate variations in risks depending on age and type of HRT initiated. Insights highlight the importance of individualized treatment strategies.

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Long-Term Risks and Benefits of HRT: Insights from the WHI Study for Women Aged 50-79

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  1. Selected Risks and Benefits after 5 Years of combined estrogen and progestogen HRT for all women aged 50-79 (WHI Study, 2002)OESTROGEN WITH PROGESTOGEN 10,000 Women Years * Not statistically significant Pulmonary Embolism 8 Breast Cancers 8 CVD* 7 Stroke 8 Increase Decrease 8 Bowel and Uterine Cancers 10 Fractures Hip and Spine MacLennan

  2. Selected Risks and Benefits after 7 Years of estrogen only HRT for all women aged 50-79 (WHI Study, 2004)OESTROGEN ONLY 10,000 Women Years * Not statistically significant Stroke 12 Pulmonary embolism* 3 Bowel Cancer* 1 Increase Decrease 5 CVD* 8 Breast Cancers* 12 Fractures Hip and Spine MacLennan

  3. Combined Estrogen + Progestogen HRT outcomes when initiated under age 60.(Data from 5,522 women in WHI Study) 10,000 Women Years ESTROGEN AND PROGESTOGEN CVD 7 Breast Cancer 2 Stroke 4 Pulmonary Embolism 1 Increase Decrease 7 Deaths . . . . 13 Diabetes 59 56 All Fractures MacLennan

  4. Estrogen only HRT outcomes when initiated under age 60(Data from 3,310 women in WHI Study) ESTROGEN ONLY 10,000 Women Years Pulmonary Embolism 1 Increase 2 Stroke 3 Total Deaths Decrease 8 Breast Cancer 11 CVD . . . . . . . . 22 59 22 Diabetes 56 All Fractures MacLennan

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