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Correlation of CLB Dose and Serum Concentration in Adult and Pediatric Patients

This study examines the correlation between the dose of clobazam (CLB) and its serum concentration in adult and pediatric patients, both with and without enzyme inducers. In adults without inducers, the serum concentration showed a strong correlation (y=804.1x, R²=0.87, r=0.75, p<0.001), while adults with inducers also exhibited significant correlation (y=349x, R²=0.79, r=0.65, p<0.001). Pediatric results indicated varying correlations depending on the presence of inducers. Results demonstrate the influence of dosing and enzyme inducers on CLB serum levels.

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Correlation of CLB Dose and Serum Concentration in Adult and Pediatric Patients

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  1. Fig. S1 Correlation between the dose of CLB and its serum concentration Adult patients without inducers y=804.1x, R2=0.87 r=0.75, p<0.001 Adult patients with inducers y=349x, R2=0.79 r=0.65, p<0.001 Serum CLB concentration (ng/ml) Serum CLB concentration (ng/ml) CLB dose (mg/kg) CLB dose (mg/kg) Pediatric patients with inducers y=232.9x, R2=0.69 r=0.50, p<0.001 Pediatric patients without inducers y=435.2x, R2=0.76 r=0.61, p<0.001 Serum CLB concentration (ng/ml) Serum CLB concentration (ng/ml) CLB dose (mg/kg) CLB dose (mg/kg) R2; coefficient of determination, r2; squared correlation coefficient

  2. Fig. S2 Effect of VPA in adult patient concomitantly using inducers Without VPA With VPA * * * * * CLB CD ratio (ng/mL)/(mg/kg) * 262 109 412 118 45 45 151 11 96 22 67 15 34 5 PHT N=371 CBZ N=530 PB N=90 PHT+CBZ N=162 PHT+PB N=118 CBZ+PB N=82 PHT+PB+CBZ N=39 Significance was determined by the unpaired t-test. *p<0.001

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