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CLB dose (mg/kg)

Fig. S1 Correlation between the dose of CLB and its serum concentration. Adult patients without inducers y=804.1x, R 2 =0.87 r =0.75, p <0.001. Adult patients with inducers y=349x, R 2 =0.79 r =0.65, p <0.001. Serum CLB concentration (ng/ml). Serum CLB concentration (ng/ml).

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CLB dose (mg/kg)

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  1. Fig. S1 Correlation between the dose of CLB and its serum concentration Adult patients without inducers y=804.1x, R2=0.87 r=0.75, p<0.001 Adult patients with inducers y=349x, R2=0.79 r=0.65, p<0.001 Serum CLB concentration (ng/ml) Serum CLB concentration (ng/ml) CLB dose (mg/kg) CLB dose (mg/kg) Pediatric patients with inducers y=232.9x, R2=0.69 r=0.50, p<0.001 Pediatric patients without inducers y=435.2x, R2=0.76 r=0.61, p<0.001 Serum CLB concentration (ng/ml) Serum CLB concentration (ng/ml) CLB dose (mg/kg) CLB dose (mg/kg) R2; coefficient of determination, r2; squared correlation coefficient

  2. Fig. S2 Effect of VPA in adult patient concomitantly using inducers Without VPA With VPA * * * * * CLB CD ratio (ng/mL)/(mg/kg) * 262 109 412 118 45 45 151 11 96 22 67 15 34 5 PHT N=371 CBZ N=530 PB N=90 PHT+CBZ N=162 PHT+PB N=118 CBZ+PB N=82 PHT+PB+CBZ N=39 Significance was determined by the unpaired t-test. *p<0.001

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