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Assessing the Computational Capacity of Functionally-Defined Networks

This study examines the computational capacity of functionally defined networks in the brain, utilizing Network Participation Indices (NPI) and regional maps. Key metrics such as connection density, transmission ratios (outputs to inputs), and symmetry of connections are analyzed to understand network dynamics. The findings highlight significant relationships between awareness and medial temporal lobe functional connectivity, revealing critical insights into the brain's network structure concerning information processing and connection efficiency. The study contributes to the understanding of how these networks support cognition.

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Assessing the Computational Capacity of Functionally-Defined Networks

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  1. The Rotman Research Institute Assessing the Computational Capacity of Functionally-Defined Networks Rolf Kötter Anthony Randal McIntosh Computational Systems Neuroscience Group C. &. O. Vogt Brain Research Institute

  2. Network Participation Indices(NPI) & Regional Maps • Density • Proportion of existing connections (afferent and efferent) relative to the number of all potential connections • 1.0 high density • Transmission • Proportion of outputs relative to the number of existing inputs and outputs • Outdegree & indegree in graph theory • T >0.5 more efferents, T<0.5 more afferents • Symmetry • Proportion of reciprocal connections relative to existing reciprocal and unidirectional connections • S >0.5 more reciprocal, S <0.5 more asymmetric Kötter & Stephan, Neural Net, 2003 Kötter & Wanke, Phil Trans R Soc B 2005

  3. RM entire matrix STRESS=0.092

  4. Awareness & Medial Temporal Lobe Functional Connectivity Aware Unaware Seed Seed Behavior Behavior McIntosh, Rajah & Lobaugh, J Neurosci, 2003

  5. Aware PFCPOL STRESS=0.076 VACV PMCVL PFCVL Density PFCORB CCP CCA PFCCL PHC V1 VACD TCPOL Single Primary Cluster Significant regions show increase in density and transmission: TC V1 (transmission greater) VACv PHC PFCpol (symmetry) PCIP TCC PCI TCS Symmetry TCI V2 M1 CCS S1 Transmission

  6. Unaware V1 STRESS=0.053 PFCVL PFCORB PHC PFCCL Density TCS CCP TCC Symmetry TCPOL PFCM Two Clusters based on density V1 isolation (no intermediate VA areas) Higher density: PFCm PFCorb PHC Reduced Transmission: PFCvl TCs IA PCI PMCVL TCI A2 Transmission

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