1. Childhood leukaemia in Great Britain: trends in incidence, survival and ‘cure’ Anjali Shah UK Association of Cancer Registries conference 30 September 2004

2. Malignant disease in children England and Wales, 1981-1990 International Incidence of Childhood Cancer, vol 2, 1999

3. Types of leukaemia in children England and Wales, 1981-1990 International Incidence of Childhood Cancer, vol 2, 1999

4. Objectives To examine long-term trends in: - Relative survival - ‘Cure’ - Incidence and mortality

5. Leukaemia categories 1901-2000International Classification of Diseases From ICD Content Categories rev. 1901– 1 Not defined─ 1911– 2-3 Leukaemia 1 1931– 4-5 Leukaemia, aleukaemia 2 1950– 6-7 Lymphatic, myeloid, monocytic 5 1968– 8 Acute, chronic 13 1979–2000 9 Subacute 25 WHO, International Classification of Diseases

6. Leukaemia incidence, mortality and survival trends England and Wales, 1911 to 2000

7. Leukaemia incidence and mortality trends England and Wales, 1911 to 2000 – by sex

8. Leukaemia incidence and mortality trends England and Wales, 1911 to 2000: 1-4 years Incidence Mortality

9. Childhood leukaemia survival by period of diagnosis Great Britain, 1971 to 1997 1993-97 1988-92 1983-87 1979-82 1975-78 1971-74

10. Childhood ALL survival by period of diagnosis Great Britain, 1971 to 1997 1988-92 1993-97 1988-92 1993-97 1983-87 1979-82 1975-78 1971-74

11. Childhood AML survival by period of diagnosis Great Britain, 1971 to 1997 1993-97 1993-97 1988-92 1983-87 1979-82 1975-78 1971-74

12. “cured” patients Relative survival and population ‘cure’ ‘Cured’ patients

13. “cured” patients Relative survival and population ‘cure’ ‘Cured’ patients Tm

14. “cured” patients Relative survival and population ‘cure’ ‘Cured’ patients Tm Tc

15. Childhood leukaemia ‘cure’ by sex Great Britain, 1971 to 1997 1993-97

16. Childhood leukaemia ‘cure’ by type of leukaemia Great Britain, 1971 to 1997 ALL ALL 1993-97 ANLL AML

17. Time to ‘cure’ by type of leukaemia Great Britain, 1971 to 1997 ALL ALL ALL 1993-97 ANLL AML AML

18. Summary • Incidence has increased by 20% between 1971 and 2000 by 24% in 1-4 year olds • Survival has increased from 31% in 1971 to 77% in 1997 • It is possible to estimate ‘cure’ by period analysis • ‘Cure’ is estimated to have increased to 71%

19. Acknowledgements • Office for National Statistics • Childhood Cancer Research Group • Clinical Trials Service Unit Funding • Foundation for Children with Leukaemia