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School of Women’s and Infants’ Health

School of Women’s and Infants’ Health. Overview of Research by Jeff Keelan. SWIH research. Major programmes Raine study; genetics; sheep studies Group-based research Obstetrics, neonatology, reproductive health, placentology.

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School of Women’s and Infants’ Health

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  1. School of Women’s and Infants’ Health Overview of Research by Jeff Keelan

  2. SWIH research • Major programmesRaine study; genetics; sheep studies • Group-based researchObstetrics, neonatology, reproductive health, placentology

  3. Raine studyPennell, Newnham, Doherty, Hart et al(plus many TICHR researchers) • WA pregnancy cohort (DoHaD resource) • 2900 women (2686 babies), 1989-91 • Ante-natal / cord blood samples, growth, development, perinatal/obstetric parameters • Follow-up at 1, 2, 3, 5, 8, 10, 14, 17-18, 20 years • Data: health, fitness, obesity, BP, asthma, nutrition/diet, mood & mental health, cognitive function, stress… • Studies: Ante-natal exposure to androgens, estrogens, vitamins, plasticizers, endocrine disrupters • Impact of genes on health and development • Ante-natal / postnatal risk factors for autism spectrum disorders

  4. Genetic Epidemiology and PredictionPennell, Palmer, Beilin, Newnham et al • GWAS, Raine cohort, epigenetics. • Genetic associations with birth weight, asthma, eczema, obesity, age of menarche, insulin resistance/glycemia • Preterm birth Genome Project (PREBIC) – 4000 women (800 to date), 75% PTB rate. • 1200 DNA samples genotyped, results pending. • Variety of other genetic associations studies in progress • Funding: Channel 7 Telethon Trust, WIRF, NHMRC, CIHR, WHO, March of Dimes Birth Defects Foundation

  5. NIH collaborationNewnham, Pillow, Kemp et al(Jobe, Kallapur) • Fetal sheep (large animal) model • Intrauterine ureaplasma infection • Fetal lung development / inflammation • Fetal lung ventilation strategies • Fetal brain development / inflammation • Fetal skin development / inflammation • Funding: NIH (20 years), NHMRC

  6. Obstetric ResearchNewnham, Dickinson, Pennell, Doherty, Simmer, Fletcher et al • Fetal futures – long term outcomes of children with antenatal & perinatal problems • Effects of fetal blood transfusions on cardiac function • Gastroschisis - long term health implications • Umbilical gas / lactate monitoring • Maternity care in remote aboriginal communities • Vascular risk factors in prediction of preeclampsia • Exercise effects on gestational diabetes • Funding: WIRF, Channel 7 Telethon Trust, NHMRC, WA Department of Health

  7. Neonatal ResearchSimmer, Pillow, Hartmann et al • Neonatal immune development, infection and late onset sepsis. • Neonatal lung function and development – ventilation strategies; diaphragm structure and development; nebulizer-based surfactant supplementation; caffeine therapy; mathematical modeling of lung epithelia during ventilation. • Neonatal nutrition – breast milk quality and quantity; alternative sterilization procedures; Prem Milk Bank; w3-PUFA supplementation, FAD genetics and infant development; probiotic supplementation; fat emulsions of parenteral nutrition. • Funding: NHMRC, SHRAC, Fisher & Paykel, Madela AG, WIRF, Raine Foundation, NIH, Channel 7 Telethon Trust, Viertel Charitable Foundation.

  8. Reproductive Health ResearchHart, Hickey, Newnham, Dickinson, Pennell, Doherty, Leung, Hammond, Salfinger et al • Early childhood origins of PCOS • Early life origins of impaired testicular function • Epidemiology, histology, genetics and treatment of ovarian cancer • Laparoscopic detection of endometrial cancer • Funding: NHMRC, WIRF, Raine Medical Research Foundation, TICHR

  9. Placental function and pathophysiologyKeelan, Waddell, Dharmarajan, Mori • Inflammation and oxidative stress in placenta and pregnancy disorders • Anti-inflammatory drugs – prevention and treatment of placental inflammation • Lipid derived mediators in pregnancy – lipoxins, resolvins, protectins, endocannabinoids, prostanoids, oxysterols, isoprostanes, lysophospholipids, sphingolipids etc • Placental differentiation – b-catenin/Akt signalling, sphingolipids (ceramide, S1P) • Placental transport – lipids, drugs, nanoparticles • Funding: NHMRC, Raine Foundation, March of Dimes Foundation

  10. Education researchMcGurgan, Carmody, Tregonning • Teaching of clinical skills in intimate examinations • Use of audience transponders in teaching • Effects of presence of medical students in delivery suites • Effects on peer review of teaching • Simulation training in obstetric emergencies • Research on professional development

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