The Affects of Acromegaly on the Heart Pamela Pierre BIO 475-03
Symptoms of Acromegaly • Headaches • Kidney failure • Arthritis • Type 2 Diabetes • Heart failure (due to the enlargement of the heart)
Physical Characteristics • Enlarged hands, arms, feet (extremities) • Enlargement of facial features -nose -tongue -lips -jaw
What causes acromegaly? • Pituitary adenoma – benign tumor in the pituitary gland • Rare cases tumor found in the lungs, pancreas, or in the adrenal glands.
Pituitary Adenoma • Growth Hormone (GH) – protein hormone responsible for growth and reproduction of cells • Insulin-like growth factor 1 (IGF-1) – responsible for growth during childhood and contributing factor behind acromegaly
Pituitary Adenoma cont. • The benign tumor causes the overproduction of GH, which then stimulates the liver to secrete IGF-1 • IGF-1 causes the overgrowth in the bones • People without acromegaly have affective way to reduce GH called the somatostatin • Somatostatin reduces the production and secretion of GH
Acromegaly on the Heart Acromegaly can cause heart failure because of the constraint on the heart. The following conditions and diseases can occur due to acromegaly: • Arterial stiffness • Aortic pressure • Cardiomyopathy • Cardiac Dysrhythmias
Acromegaly of the Heart Causes the change of the structure and function of the heart.
Cardiomyopathy • Cardiomyopathy literally means “heart muscle disease” • Condition where the number of myocytes increases within the ventricular walls without the cardiac chambers increasing in size.
Cardiac Dysrhythmias • Are conditions where the electrical activities of the heart is evaluated. • People who suffer from acromegaly usually suffer from irregular electrical activities or either dysrhythmias causes the electrical impulses to occur faster or slower than usual.
References Images provided by: • www.faqs.org • http://www.acromegaly.org.uk/acromegaly.jpg • http://johnkstuff.blogspot.com/uploaded_images/pamela-734833.jpg • http://upload.wikimedia.org/wikipedia/commons/1/1e/Idiopathic_cardiomyopathy%2C_gross_pathology_20G0018_lores.jpg
References • http://www.umm.edu/graphics/images/en/18092.jpg • http://upload.wikimedia.org/wikipedia/commons/8/85/EKG_VF.jpg • http://www.mercksource.com/ppdocs/us/common/dorlands/dorland/chapters/images/w0146_e_6.jpg