Cold Chain Shipping Research Project

1. Cold Chain ShippingResearch Project The Pennsylvania State University The Smeal College of Business December 7th, 2009 Sam Shampain

2. Agenda • Project Background • Cold Chain Shipping in the Biological Industry • Cold Chain Shipping in the Pharmaceutical Industry • Cold Chain Shipping in the Food Industry • General Packaging Solutions for Cold Chain Shipping • Recommendations BD Biosciences/Penn State Cold Chain Shipping Project

3. Agenda • Project Background • Cold Chain Shipping in the Biological Industry • Cold Chain Shipping in the Pharmaceutical Industry • Cold Chain Shipping in the Food Industry • General Packaging Solutions for Cold Chain Shipping • Recommendations BD Biosciences/Penn State Cold Chain Shipping Project

4. Project Background • Becton Dickinson ships single/multiple doses to customers both internationally and domestically • The cold chain industry has become increasingly more challenging: • More government regulation • More customer preferences • Unreliable Infrastruture • Globalized economy BD Biosciences/Penn State Cold Chain Shipping Project

5. Project Background • Companies are beginning to focus on making their cold chain shipping a core competency • Research was conducted with the following goals: • Define the industry standard • Benchmark current BD Bioscience's practices against standard • Offer viable alternatives to current practices BD Biosciences/Penn State Cold Chain Shipping Project

6. Agenda • Project Background • Cold Chain Shipping in the Biological Industry • Cold Chain Shipping in the Pharmaceutical Industry • Cold Chain Shipping in the Food Industry • General Packaging Solutions for Cold Chain Shipping • Recommendations BD Biosciences/Penn State Cold Chain Shipping Project

7. Biological Industry • Trends • Reusable Packaging, Eco-Friendly Packaging • RFID tags, Data Logging, theft prevention • Best Practices • Beckman Coulter - Hired prominent 3PL, Arvato Services • Created regional distribution centers • Built replacement parts DC next to Brussels airport • eBioscience - Purchase NatuTec a German bio company • Offered faster lead times to Europe • Wider range of products BD Biosciences/Penn State Cold Chain Shipping Project

8. Agenda • Project Background • Cold Chain Shipping in the Biological Industry • Cold Chain Shipping in the Pharmaceutical Industry • Cold Chain Shipping in the Food Industry • General Packaging Solutions for Cold Chain Shipping • Recommendations BD Biosciences/Penn State Cold Chain Shipping Project

9. Pharmaceutical Industry • Trends • Switching from passive to active cooling systems • Alternatives to dry ice • Best Practices • Cold Chain Technologies - Global 3PL provider/manufacturer • All of there products meet all regulations • Sustainable, reusable, eco-friendly products • Minnesota Thermal Sciences - Packaging Manufacturer • Fully ISTA certified • Won “US Army Greatest Invention Award” for Golden Hour Container BD Biosciences/Penn State Cold Chain Shipping Project

10. Agenda • Project Background • Cold Chain Shipping in the Biological Industry • Cold Chain Shipping in the Pharmaceutical Industry • Cold Chain Shipping in the Food Industry • General Packaging Solutions for Cold Chain Shipping • Recommendations BD Biosciences/Penn State Cold Chain Shipping Project

11. Food Industry • Trends • Increased regulations because of disease outbreak • Global sourcing, trading partner collaboration, sustainability • Best Practices • Cross-Docking - Cuts inventory, labor, transportation costs • Increased pressure from customer for variety, freshness, customer service • Outsourcing shipping practices • Many companies using a 3PL for refrigerated shipping • Temperature Monitors/RFID • Improves perfect order accuracy/less spoilage BD Biosciences/Penn State Cold Chain Shipping Project

12. Agenda • Project Background • Cold Chain Shipping in the Biological Industry • Cold Chain Shipping in the Pharmaceutical Industry • Cold Chain Shipping in the Food Industry • General Packaging Solutions for Cold Chain Shipping • Recommendations BD Biosciences/Penn State Cold Chain Shipping Project

13. Cold Chain Industry - Leading Companies • Cold Pack • US offices located in San Diego, California • Produces award-winning “Airliner” product • “Revolutionary inflatable, insulating liner that easily converts a corrugated box into a cooler” • Entropy Solutions • Based in Minnesota - Competes in 35 countries globally • Produces award-winning, EPS substitute, “Greenbox” • Known for their 100% organic, yet extremely effective packaging solutions BD Biosciences/Penn State Cold Chain Shipping Project

14. Emerging Packaging Solutions • Vacuum Insulated Panels (VIPS) • Highest R-Value of any box liner • Typically used to insulate houses • Extremely effective yet very costly • As market expands prices will decrease • Dry Ice Alternatives • Dry Ice produces harmful CO2 and creates handling problems • Safer, more eco-friendly substitutes are coming to the market • Effectiveness not quite known BD Biosciences/Penn State Cold Chain Shipping Project

15. Agenda • Project Background • Cold Chain Shipping in the Biological Industry • Cold Chain Shipping in the Pharmaceutical Industry • Cold Chain Shipping in the Food Industry • General Packaging Solutions for Cold Chain Shipping • Recommendations BD Biosciences/Penn State Cold Chain Shipping Project

16. Considerations • Packaging requirements of BD Biosciences • Maintain 2-8 oC or 2-25 oC for 24 hours • Maintain 2-8 oC or 2-25 oC for 5 days • Alternatives to Dry Ice • Aspects Considered • Environmentally friendly • Cost effective • Minimal Assembly • Packaging Integrity BD Biosciences/Penn State Cold Chain Shipping Project

17. Recommendations • Maintain 2-8 oC or 2-25 oC for 24 hours • ColdPack’s Airliner • Greenbox Inflater Pack with E23 Phase-Change Materials manufactured by Entropy Solutions • KoolTemp™ Insulated Envelopes manufactured by Cold Chain Technologies BD Biosciences/Penn State Cold Chain Shipping Project

18. ColdPack’s Airliner • Inflatable bag that can be used as a box liner or shipping pouch • Awards • European Pharmapack Cold Chain Award- for innovative medical shipping • FPA (Flexible Packaging Association) 2009 Gold Achievement Award in Packaging Excellence BD Biosciences/Penn State Cold Chain Shipping Project

19. Greenbox Inflater Pack • Single dose package that must be combined with a gel pack • Walmart uses the Inflater Pack for all of their single dose shipments • Awards • 2009 Greener Package Award • “Innovator of the Year” BD Biosciences/Penn State Cold Chain Shipping Project

20. KoolTemp™ Insulated Envelopes • Insulated envelope that can be used with gel packs/dry ice • May be shipped within standard overnight box for added protective • Envelope and payload must be chilled to temperature profile before shipment BD Biosciences/Penn State Cold Chain Shipping Project

21. Recommendations • Maintain 2-8 oC or 2-25 oC for 5 days • KoolTemp Polyurethane Insulated Cooler • Entropy Solution’s GreenBox BD Biosciences/Penn State Cold Chain Shipping Project

22. KoolTemp PU Insulated Cooler • Polyurethane insulated cooler ships within outer corrugated box • Much higher R Value than EPS or XPS • Contains no CFCs or HCFCs BD Biosciences/Penn State Cold Chain Shipping Project

23. Entropy Solution’s GreenBox • The Greenbox can maintain payload temperatures from -40°C to +70°C for up to 120+ hours or five days • Contains Thermal-Lok™ insulation panels with a R Value 10 times greater than EPS • Awards • Greener Package Award and “Innovator of the Year.” BD Biosciences/Penn State Cold Chain Shipping Project

24. Recommendations • Alternatives to Dry Ice • Entropy Solutions: The PureTemp - 40 Solution • Techni Ice™ Reusable Dry Ice Packs • TCP Reliable’s ‘20 below’ BD Biosciences/Penn State Cold Chain Shipping Project

25. The PureTemp - 40 Solution • Insulating panels that surround and insulate the product • First sustainable dry ice alternative to come to the market • Department of Agriculture lists the material in its Bio-preferred purchasing program BD Biosciences/Penn State Cold Chain Shipping Project

26. Techni Ice™ Reusable Dry Ice Packs • Dry Ice pack that must be hydrated then frozen down to the required temperature • Has recreational and commercial uses BD Biosciences/Penn State Cold Chain Shipping Project

27. TCP Reliable’s ‘20 Below’ • Serves specific temperature profile from -25 to -20 degrees • Available as a panel or as a pouch BD Biosciences/Penn State Cold Chain Shipping Project

28. Conclusion • Entire Industry looking to move away from using standard EPS foam • Focusing on more environmentally friendly substitutes • Reusable options - can aid reverse logistics • Eco-friendly and sustainable shipping practices can be a competitive advantage • Cold Chain Shipping is a rapidly expanding industry • The companies that succeed will be those who stay ahead of the innovation curve BD Biosciences/Penn State Cold Chain Shipping Project

29. Thank You !